Risks associated with endotoxins in feed additives produced by fermentation.
Risks associated with endotoxins in feed additives produced by fermentation.
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DOI：
10.1186/s12940-016-0087-2
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发表时间：
2016-01-15
期刊：
影响因子：
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通讯作者：
Leng L
中科院分区：
文献类型：
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作者：
Wallace RJ;Gropp J;Dierick N;Costa LG;Martelli G;Brantom PG;Bampidis V;Renshaw DW;Leng L
越来越多的家畜饲料添加剂，如氨基酸和维生素，正由革兰氏阴性菌产生，特别是大肠杆菌。因此，动物、消费者和工人可能会暴露在这些产品中可能有害的内毒素中。本综述的目的是评估饲料添加剂中内毒素的风险程度，并计算如何从添加剂的性质来评估这种风险。家畜经常暴露于饲料中相对较高的内毒素含量：如果饲料添加剂的内毒素浓度降至与饲料相同的范围，预计不会对家畜造成额外的危害。消费者摄入含有内毒素饲料的动物的食物不会影响消费者的暴露，因为所吸收的小浓度内毒素不会在可食用组织中积聚。相比之下，加工尘土飞扬的添加剂的工人可能会暴露在危险剂量的内毒素中，即使产品的内毒素浓度很低。提出了一种计算方法，根据粉尘潜力、内毒素浓度和欧洲食品安全局的技术指导，将对工人的潜在风险与国家暴露限值进行比较。
Increasingly, feed additives for livestock, such as amino acids and vitamins, are being produced by Gram-negative bacteria, particularly Escherichia coli. The potential therefore exists for animals, consumers and workers to be exposed to possibly harmful amounts of endotoxin from these products. The aim of this review was to assess the extent of the risk from endotoxins in feed additives and to calculate how such risk can be assessed from the properties of the additive. Livestock are frequently exposed to a relatively high content of endotoxin in the diet: no additional hazard to livestock would be anticipated if the endotoxin concentration of the feed additive falls in the same range as feedstuffs. Consumer exposure will be unaffected by the consumption of food derived from animals receiving endotoxin-containing feed, because the small concentrations of endotoxin absorbed do not accumulate in edible tissues. In contrast, workers processing a dusty additive may be exposed to hazardous amounts of endotoxin even if the endotoxin concentration of the product is low. A calculation method is proposed to compare the potential risk to the worker, based on the dusting potential, the endotoxin concentration and technical guidance of the European Food Safety Authority, with national exposure limits.