Chiral bisphosphine ligands based on quinoline oligoamide foldamers: application in asymmetric hydrogenation.
Chiral bisphosphine ligands based on quinoline oligoamide foldamers: application in asymmetric hydrogenation.
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DOI：
10.1039/c9ob01649j
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发表时间：
2019-11
影响因子：
3.2
通讯作者：
Lu Zheng;Dan Zheng;Yanru Wang;Chengyuan Yu;Kun Zhang;Hua Jiang
中科院分区：
文献类型：
--
作者：
Lu Zheng;Dan Zheng;Yanru Wang;Chengyuan Yu;Kun Zhang;Hua Jiang
设计并合成了一系列基于单手喹啉低聚酰胺类化合物的手性双膦配体。双膦配体与Rh(Cod)2BF4以1：1的化学计量比配位，得到的手性Rh(I)催化剂用于α-脱氢氨基酸酯的不对称氢化反应，获得了良好的转化率和良好的对映选择性。
A series of chiral bisphosphine ligands were designed and synthesized based on single-handed quinoline oligoamide foldamers. The bisphosphine ligands can coordinate with Rh(cod)2BF4 in a 1 : 1 stoichiometry and the resulted chiral Rh(i) catalysts were applied in the asymmetric hydrogenation of α-dehydroamino acid esters, in which excellent conversions and promising levels of enantioselectivity were achieved.