THICK ASCENDING LIMB OF HENLES LOOP
THICK ASCENDING LIMB OF HENLES LOOP
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DOI：
10.1038/ki.1982.198
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发表时间：
1982-01-01
影响因子：
19.6
通讯作者：
BURG, MB
中科院分区：
文献类型：
--
作者：
BURG, MB
1966年首次对亨利袢的粗升支进行了直接研究[1]。当时，研究采用了最近描述的从新鲜兔肾中解剖肾小管的技术[2]。测定细胞内钠、钾含量和交换。7年后，该节段首次在体外灌注[3，4]，并观察到活性氯化物吸收。后来，在两栖动物[5]和淡水硬骨鱼[6]的远端小管（“稀释节”）中发现了一个明显相同的运输系统。在进化过程中，这种特殊的主动氯离子运输系统的保护表明了一种重要的功能。在下文中，我总结了已经发表的关于粗升支和稀释段的直接研究，以分析所涉及的转运机制并推测其功能意义。
The first direct studies of thick ascending limbs of Henle's loop were made in 1966 [1]. At that time, the studies utilized a recently described technique for dissecting renal tubules from fresh rabbit kidneys [2]. Cellular content and exchange of sodium and potassium were measured. Seven years later this segment was first perfused in vitro [3, 4], and active chloride absorption was observed. Later, an apparently identical transport system was discovered in amphibia [5] and fresh water teleosts [6] in their distal tubules (“diluting segments”). The conservation of this specialized system of active chloride transport through the evolutionary process suggests an important function. In the following I summarize the direct studies that have been published on thick ascending limbs and diluting segments to analyze the transport mechanisms involved and speculate on their functional significance.