Toward the future of psychiatric diagnosis: the seven pillars of RDoC.
Toward the future of psychiatric diagnosis: the seven pillars of RDoC.
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DOI：
10.1186/1741-7015-11-126
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发表时间：
2013-05-14
期刊：
影响因子：
9.3
通讯作者：
Insel TR
中科院分区：
文献类型：
--
作者：
Cuthbert BN;Insel TR
目前精神障碍的诊断系统依赖于出现症状和体征，结果是，目前的定义不能充分反映相关的神经生物学和行为系统--这不仅阻碍了病因学和病理生理学的研究，也阻碍了新治疗方法的开发。国家精神卫生研究所于2009年启动了研究领域标准(RDoC)项目，以神经生物学和可观察行为的维度为基础，开发精神障碍的研究分类系统。RDoC支持研究，以阐明跨越当前异质性障碍类别的基本生物行为维度。我们总结了RDoC的理论基础、现状和长期目标，概述了开发研究分类系统的挑战(例如结构效度和更新框架的合适过程)，并讨论了与当前精神病学研究在概念和重点上的七个明显差异。在围绕这些学科组织的文献可用于为修订工作提供信息之前，未来的诊断系统无法反映遗传学、神经科学和认知科学的持续进展。RDoC项目的目标是为研究提供一个框架，以改变精神障碍病因学的方法。
Current diagnostic systems for mental disorders rely upon presenting signs and symptoms, with the result that current definitions do not adequately reflect relevant neurobiological and behavioral systems - impeding not only research on etiology and pathophysiology but also the development of new treatments. The National Institute of Mental Health began the Research Domain Criteria (RDoC) project in 2009 to develop a research classification system for mental disorders based upon dimensions of neurobiology and observable behavior. RDoC supports research to explicate fundamental biobehavioral dimensions that cut across current heterogeneous disorder categories. We summarize the rationale, status and long-term goals of RDoC, outline challenges in developing a research classification system (such as construct validity and a suitable process for updating the framework) and discuss seven distinct differences in conception and emphasis from current psychiatric nosologies. Future diagnostic systems cannot reflect ongoing advances in genetics, neuroscience and cognitive science until a literature organized around these disciplines is available to inform the revision efforts. The goal of the RDoC project is to provide a framework for research to transform the approach to the nosology of mental disorders.