Serum nesfatin-1 is reduced in type 2 diabetes mellitus patients with peripheral arterial disease.
Serum nesfatin-1 is reduced in type 2 diabetes mellitus patients with peripheral arterial disease.
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DOI：
10.12659/msm.892611
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发表时间：
2015-04-04
期刊：
影响因子：
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通讯作者：
Wang J
中科院分区：
文献类型：
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作者：
Ding S;Qu W;Dang S;Xie X;Xu J;Wang Y;Jing A;Zhang C;Wang J
最近发现的Nesfatin-1是一种饱腹感调节因子，具有抗动脉粥样硬化的作用。我们的研究旨在确定血清nesfatin-1与2型糖尿病（T2DM）患者外周动脉疾病（PAD）的发展和严重程度之间是否存在关联。本横断面研究纳入355例T2DM患者（200例无PAD， 155例有PAD）。伴有PAD的T2DM患者血清nesfatin-1浓度明显低于无PAD的T2DM患者。多变量logistic回归分析显示，血清nesfatin-1浓度与T2DM患者PAD的发展呈负相关（OR 0.008, 95% CI 0.002 ~ 0.028； P<0.001）。简单线性回归分析显示，T2DM患者血清nesfatin-1浓度与体重指数（BMI）、胰岛素抵抗稳态模型评估（HOMA-IR）、c反应蛋白（CRP）和踝肱指数（ABI）存在显著相关性。相比之下，多变量分析显示只有BMI和ABI是血清nesfatin-1的独立相关因素。我们的研究显示血清nesfatin-1浓度与T2DM患者PAD的发展和严重程度有关。
Nesfatin-1, recently identified as a satiety regulator, elicits an anti-atherosclerosis effect. Our study was designed to determine whether there is an association between serum nesfatin-1 and the development and severity of peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM). This cross-sectional study included 355 T2DM patients (200 without PAD and 155 with PAD). T2DM patients with PAD exhibited marked lower serum nesfatin-1 concentrations than those without PAD. Multivariable logistic regression analysis indicated an inverse association of serum nesfatin-1 concentrations with the development of PAD in T2DM patients (OR 0.008, 95% CI 0.002 to 0.028; P<0.001). Simple linear regression analysis showed a marked correlation between serum nesfatin-1 concentrations and body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein (CRP), and ankle-brachial index (ABI) in T2DM patients. By contrast, multivariable analysis showed only BMI and ABI as independent correlates of serum nesfatin-1. Our study shows an association of serum nesfatin-1 concentrations and the development and severity of PAD in T2DM patients.