Cancer-targeting multifunctionalized gold nanoparticles in imaging and therapy.
Cancer-targeting multifunctionalized gold nanoparticles in imaging and therapy.
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DOI：
10.2174/092986711795656199
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发表时间：
2011-05
影响因子：
4.1
通讯作者：
P. Jiao;H. Zhou;Lingxin Chen;Bing Yan
中科院分区：
文献类型：
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作者：
P. Jiao;H. Zhou;Lingxin Chen;Bing Yan
纳米技术为靶向癌症成像和治疗提供了许多有前景的纳米平台。在这些平台中，金纳米粒子（GNP）因其优异的物理和化学性质在医学中发挥着独特的作用。为了扩大 GNP 在医学上的应用，大量的靶向部分、成像标记和治疗剂已被整合到这些颗粒中，形成多功能化的 GNP。在这篇综述中，我们重点介绍了癌症靶向多功能 GNP 的制造及其在成像和治疗中的应用的最新进展。
Nanotechnology has provided many promising nanoplatforms for targeted cancer imaging and therapy. Among these platforms, gold nanoparticles (GNPs) play a unique role in medicine because of their excellent physical and chemical properties. To expand the applications of GNPs in medicine, amounts of targeting moieties, imaging labels, and therapeutic agents have been integrated into these particles to form multifunctionalized GNPs. In this review, we highlight recent advances of the fabrication of cancer-targeting multifunctionalized GNPs and their applications in imaging and therapy.