A gluconeogenic tryst in the nucleus, with ER stress as the third wheel.
A gluconeogenic tryst in the nucleus, with ER stress as the third wheel.
复制标题
细胞核内的糖异生幽会，内质网应激作为第三轮。
DOI：
10.1126/scisignal.296pe72
复制
发表时间：
2009
影响因子：
7.3
通讯作者：
Rutkowski,DThomas
中科院分区：
文献类型：
--
作者：
Rutkowski,DThomas
细胞的转录输出反映了数百个转录调节因子之间的合作和竞争相互作用的总和，这些转录调节因子本身根据细胞条件进行调节。通过这种方式，不同的信号级联在基因表达水平上交叉;当细胞努力整合来自多个途径的信息时，细胞一个区域的扰动必然会从根本上影响其他区域。这种转录串扰的后果是突出了一个新发现的连接，通过一个共同的共调节，在内质网和控制的压力之间的同源性。这些发现暗示了应激途径作为基础细胞内稳态调节器的可能功能。
The transcriptional output of a cell reflects the sum of cooperative and competing interactions among hundreds of transcriptional regulators that are themselves regulated according to cellular conditions. In this way, disparate signaling cascades intersect at the level of gene expression; perturbation in one area of the cell will necessarily and fundamentally affect other areas as the cell strives to integrate information from multiple pathways. The consequences of such transcriptional cross-talk are highlighted by a newly discovered connection, through a common co-regulator, between stress in the endoplasmic reticulum and control of gluconeogenesis. These findings hint at the possible functions of stress pathways as regulators of basal cellular homeostasis.