The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules
The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules
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DOI：
10.1128/jvi.76.22.11753-11756.2002
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发表时间：
2002-11-01
影响因子：
5.4
通讯作者：
Ploegh, HL
中科院分区：
文献类型：
--
作者：
Furman, MH;Dey, N;Ploegh, HL
人类巨细胞病毒（HCMV）US10编码一种糖蛋白，能与主要组织相容性复合体（MHC）I类重链结合。虽然 US10 的表达会延迟 MHC I 类分子从内质网正常运出，但 US10 并不明显促进或抑制另外两种 HCMV 编码的 MHC I 类结合蛋白 US2 和 US11 的作用。
Human cytomegalovirus (HCMV) US10 encodes a glycoprotein that binds to major histocompatibility complex (MHC) class I heavy chains. While expression of US10 delays the normal trafficking of MHC class I molecules out of the endoplasmic reticulum, US10 does not obviously facilitate or inhibit the action of two other HCMV-encoded MHC class I binding proteins, US2 and US11.