Significance and Mechanism of Lymph Node Metastasis in Cancer Progression
Significance and Mechanism of Lymph Node Metastasis in Cancer Progression
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DOI：
10.1158/0008-5472.can-10-3277
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发表时间：
2011-02-15
期刊：
影响因子：
11.2
通讯作者：
Taketo, Makoto M.
中科院分区：
文献类型：
--
作者：
Kawada, Kenji;Taketo, Makoto M.
局部治疗，如外科淋巴清扫和放射治疗，对癌症患者生存的影响已经争论了几十年。最近的一些临床证据支持淋巴结转移在癌细胞全身性扩散中的重要作用，尽管由于有争议的数据，手术切除淋巴结对生存率的影响历来被淡化。对LN转移的分子研究表明，LN内的微环境，包括趋化因子和淋巴管生成，可以介导转移到前哨LN甚至更远的地方。已有研究表明，趋化因子受体CXCR3参与了LN的转移，抑制其表达可能改善患者的预后。虽然局部治疗是通过LN剥离还是通过切除和放疗相结合的方法仍然是确定的，但防止区域转移是癌症患者获得更好生存的一个重要目标。巨蟹座；71(4)；1214-8。(C)2011年AACR。
The effect of local therapy, such as surgical lymph node (LN) dissection and radiotherapy, on the survival of cancer patients has been debated for decades. Several lines of recent clinical evidence support that LN metastasis plays significant roles in systemic dissemination of cancer cells, although the effects of surgical LN dissection on survival was downplayed historically because of controversial data. Molecular studies of LN metastasis suggest that the microenvironment within LNs, including chemokines and lymphangiogenesis, can mediate the metastatic spread to the sentinel LNs, and beyond. It has been shown that chemokine receptor CXCR3 is involved in LN metastasis, and its inhibition may improve patient prognosis. Although it remains to be determined whether local therapy is best pursued through LN dissection or through a combination of resection with radiation, prevention of regional metastases is an important goal in the treatment of cancer patients to achieve a better survival. Cancer Res; 71( 4); 1214-8. (C)2011 AACR.