Trained and amphetamine-induced circling behavior in lesioned, transplanted rats.
Trained and amphetamine-induced circling behavior in lesioned, transplanted rats.
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对受损的移植大鼠进行训练和安非他明诱导的绕圈行为。
DOI：
10.1155/np.1993.157
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Freed,CR
中科院分区：
文献类型：
--
作者：
Richards,JB;Sabol,KE;Kriek,EH;Freed,CR
大鼠被训练转向水强化，然后给予单侧6 -羟多巴胺损伤。病变后，大鼠表现出对侧和同侧病变侧的训练转向功能缺失，对侧转向功能受损更严重。病变大鼠纹状体内植入胎儿中脑多巴胺组织。病变大鼠作假移植对照组。移植后4周，使用1.5 mg/kg D‐安非他明激发注射来测试移植的功能。在对照大鼠中，D‐安非他明诱导同侧翻转；在移植大鼠中，D -安非他明减缓了同侧旋转的速度或逆转了安非他明诱导的旋转方向。只有在移植后逆转安非他明诱导的转向的大鼠才被用于其余的实验。移植后4周、8周、12周和16周评估训练转身。移植在移植后的任何时间都没有提高学习成绩。当D -安非他明与训练转身同时使用时，低剂量（0.12 mg/kg）可提高对侧训练转身率，而不影响同侧转身率。高剂量的安非他明降低了移植动物的同侧旋转率。这项研究的结果表明，移植本身并不能恢复条件旋转的表现。
Rats were trained to turn for water reinforcement and then were given unilateral 6‐ hydroxydopamine lesions. After lesion, rats showed deficits in trained turning both contraand ipsilateral to the side of the lesion, with contralateral turning more severely impaired. The lesioned rats were then transplanted with fetal mesencephalic dopamine tissue into striatum. A control group of lesioned rats were sham transplanted. Four weeks after transplant, 1.5 mg/kg D‐amphetamine challenge injections were used to test the functioning of the transplants. In the control rats, D‐amphetamine induced ipsilateral turning; in transplanted rats, D‐amphetamine slowed the rate of ipsilateral turning or reversed the direction of amphetamine‐induced rotation. Only rats which reversed their, amphetamine‐induced turn direction after transplant were used for the rest of the experiment. Trained turning was assessed at 4, 8, 12 and 16 weeks post transplant. Transplants did not improve learned performance at any time post transplant. When D‐amphetamine was administered in conjunction with the trained turning sessions, a low dose (0.12 mg/kg) enhanced contralateral trained turn rates, without affecting ipsilateral turn rates. Higher doses of amphetamine reduced ipsilateral turn rate in the transplanted animals. The results of this study suggest that transplants alone do not reinstate performance of conditioned rotation.