Perseverative thought: a robust predictor of response to emotional challenge in generalized anxiety disorder and major depressive disorder.
Perseverative thought: a robust predictor of response to emotional challenge in generalized anxiety disorder and major depressive disorder.
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坚持不懈的思想：广泛性焦虑症和重度抑郁症对情绪挑战反应的有力预测因子。
DOI：
10.1016/j.brat.2011.10.001
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发表时间：
2011
影响因子：
4.1
通讯作者：
Hallion,LaurenS
中科院分区：
文献类型：
--
作者：
Ruscio,AyeletMeron;Seitchik,AllisonE;Gentes,EmilyL;Jones,JasonD;Hallion,LaurenS
广泛性焦虑症（GAD）和重性抑郁症（MDD）经常共同发生，但其共同发病的原因仍然知之甚少。在本实验中，我们测试了是否倾向于从事消极的，重复的思维构成了两种疾病的共同风险过程。对患有GAD-MDD共病（n=50）、仅GAD（n=35）、仅MDD（n=34）或无终生精神病理学（n=35）的成年人混合样本进行了连续表现任务的非偶然失败和成功反馈。持续性思维（PT），通过在专注呼吸的基线期内的负面思想入侵来测量，成为对这个实验挑战的反应的一个强大的前瞻性预测因子。参与者在基线时报告更频繁的负面思想入侵，无论思想内容或诊断状态如何，对失败表现出更强的负面反应，即使在随后的成功之后也会持续存在。在实验过程中，较高的PT与后来的行为回避、消极情绪和其他与焦虑和抑郁密切相关的特质以及GAD和MDD的存在和严重程度相关。这些发现为广泛定义的PT性状提供了证据，该性状为GAD和MDD所共有，并导致这些疾病的不良结局。
Generalized anxiety disorder (GAD) and major depressive disorder (MDD) frequently co-occur, yet the reasons for their comorbidity remain poorly understood. In the present experiment, we tested whether a tendency to engage in negative, repetitive thinking constitutes a common risk process for the two disorders. A mixed sample of adults with comorbid GAD–MDD (n=50), GAD only (n=35), MDD only (n=34), or no lifetime psychopathology (n=35) was administered noncontingent failure and success feedback on consecutive performance tasks. Perseverative thought (PT), measured by negative thought intrusions during a baseline period of focused breathing, emerged as a powerful prospective predictor of responses to this experimental challenge. Participants reporting more frequent negative thought intrusions at baseline, irrespective of thought content or diagnostic status, exhibited a stronger negative response to failure that persisted even after subsequent success. Higher PT over the course of the experiment was associated with later behavioral avoidance, with negative affect and other traits closely linked to anxiety and depression, and with the presence and severity of GAD and MDD. These findings provide evidence for a broadly-defined PT trait that is shared by GAD and MDD and contributes to adverse outcomes in these disorders.