Plasma and urine betaine and dimethylglycine variation in healthy young male subjects
Plasma and urine betaine and dimethylglycine variation in healthy young male subjects
复制标题
DOI：
10.1016/j.clinbiochem.2009.02.001
复制
发表时间：
2009-05-01
影响因子：
2.8
通讯作者：
George, Peter M.
中科院分区：
文献类型：
--
作者：
Lever, Michael;Atkinson, Wendy;George, Peter M.
目的：我们的目的是比较血浆和尿甜菜碱和N，N-二甲基glycine.Design和方法的个性（受试者一致性内）：在两个独立的组8名男性（年龄19至40），血浆（10）和尿液（6）样本收集超过一天或超过8周的时间。甜菜碱和N，N-二甲基甘氨酸血浆浓度和排泄的个体性通过单因素重复测量方差分析进行估计。计算了信度系数和个性指数。结果：血浆甜菜碱浓度在24小时和8周内在受试者之间有显著差异（P < 0.05），血浆甜菜碱浓度在受试者之间有显著差异（P < 0.05），尿甜菜碱浓度在受试者之间有显著差异（P < 0.05），血浆甜菜碱浓度在受试者之间有显著差异（P < 0.05）。
Objectives: We aimed to compare the individuality (within subject consistency) of plasma and urine betaine and N,N-dimethylglycine.Design and methods: In two separate groups of 8 males (ages 19 to 40), plasma (10) and urine (6) samples were collected either over a single day or over an 8 week period. The individuality of the betaine and N,N-dimethylglycine plasma concentrations and excretions were estimated by one-way repeated measures analysis of variance. The reliability coefficients and indices of individuality were calculated. The between-subject variation in the study population was compared with that in a normal population (n=192 for plasma, 205 for urine).Results: Plasma betaine concentrations were significantly different between subjects over 24 h and 8 weeks (p