Translational issues in targeting brown adipose tissue thermogenesis for human obesity management
Translational issues in targeting brown adipose tissue thermogenesis for human obesity management
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DOI：
10.1111/nyas.12304
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发表时间：
2013-01-01
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影响因子：
--
通讯作者：
Dulloo, Abdul G.
中科院分区：
文献类型：
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作者：
Dulloo, Abdul G.
最近在揭示控制棕色脂肪组织 (BAT) 的诱导、（反式）分化、增殖、生热活性和能力的新机制方面取得的进展，加上成像技术在人类 BAT 可视化中的应用，令人乐观地认为，这些进展将为针对 BAT 生热作用提供新的策略，从而实现有效和安全的肥胖治疗。本文首先概述了过去几十年来的里程碑事件，这些事件一直在推动寻找药物和营养化合物，以增加肥胖管理的 BAT 生热作用。然后，它讨论了理想的生热抗肥胖方法的预期结果，特别是每日能量消耗需要增加到什么程度才能实现目前只能通过减肥手术才能实现的长期减肥，以及人体是否有足够的生热能力来通过未来以 BAT 为重点的疗法来达到减肥目标。
The recent advancements in unraveling novel mechanisms that control the induction, (trans) differentiation, proliferation, and thermogenic activity and capacity of brown adipose tissue (BAT), together with the application of imaging techniques for human BAT visualization, have generated optimism that these advances will provide novel strategies for targeting BAT thermogenesis, leading to efficacious and safe obesity therapies. This paper first provides an overview of landmark events of the past few decades that have been driving the search for pharmaceutical and nutraceutical compounds that would increase BAT thermogenesis for obesity management. It then addresses issues about what could be expected from an ideal thermogenic antiobesity approach, in particular to what extent daily energy expenditure will need to increase in order to achieve long-term weight loss currently achievable only through bariatric surgery, and whether the human body will have enough thermogenic capacity to reach this target weight loss by future therapies focused on BAT.