Candidate AIDS vaccines.
Candidate AIDS vaccines.
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候选艾滋病疫苗。
DOI：
10.1056/nejm199511163332007
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
Wright,PF
中科院分区：
文献类型：
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作者：
Graham,BS;Wright,PF
迫切需要控制人类免疫缺陷病毒1型（HIV-1）感染的全球流行。虽然教育的方法来修改冒险行为是预防的一个重要组成部分，我们集中在疫苗开发的状态进行讨论。针对其他传染病的主动免疫的成功使免疫成为预防HIV-1感染的一种有吸引力的方法。消灭天花1和在消灭脊髓灰质炎方面取得的进展（目标是到2000年实现）2是疫苗接种影响的显著例子。然而，鉴于HIV-1发病机制的复杂性，经验方法在以前的发展中取得了成功。
There is an urgent need to control the global epidemic of human immunodeficiency virus type 1 (HIV-1) infection. Although educational approaches to modify risk-taking behavior are a critical component of prevention, we focus this discussion on the status of vaccine development. The success of active immunization against other infectious diseases makes immunization an attractive approach to preventing HIV-1 infection. The eradication of smallpox1and progress in the elimination of poliomyelitis, targeted to occur by the year 2000,2are notable examples of the impact of vaccination.Given the complexity of HIV-1 pathogenesis, however, empirical approaches successful in the development of previous . . .