Consumption of fruit and vegetable and risk of coronary heart disease: A meta-analysis of prospective cohort studies
Consumption of fruit and vegetable and risk of coronary heart disease: A meta-analysis of prospective cohort studies
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DOI：
10.1016/j.ijcard.2015.01.077
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发表时间：
2015-03-15
影响因子：
3.5
通讯作者：
Lu, Zuxun
中科院分区：
文献类型：
--
作者：
Gan, Yong;Tong, Xinyue;Lu, Zuxun
背景：观察性研究表明，食用水果和蔬菜与冠心病(CHD)之间存在关联。然而，结果并不一致。方法：通过检索PubMed、Embase和Web of Science数据库，确定相关前瞻性研究。采用随机效应模型计算合并相对危险度(RR)和95%可信区间(CI)。结果：共纳入23项研究，涉及937,665名参与者和18,047名冠心病患者。与总水果蔬菜、水果蔬菜最低消费水平相比，冠心病的相对危险度分别为0.84(95%CI，0.79~0.90)、0.86(95%CI，0.82~0.91)、0.87(95%CI，0.81~0.93)。剂量-反应分析显示，每477 g/d果蔬总摄入量患冠心病的相对危险度为0.88(95%CI：0.85~0.91)，每300 g水果摄入量患冠心病的RR为0.84(95%CI：0.75~0.93)，每400 g/d蔬菜摄入量患冠心病的相对危险度为0.82(95%CI：0.73~0.92)。研究发现，单独食用水果或蔬菜与冠心病风险之间存在非线性关联(P代表非线性
Background: Observational studies suggest that an association between fruit and vegetable consumption and coronary heart disease (CHD). However, the results are inconsistent. We conducted a meta-analysis to evaluate the relationship of fruit and vegetable consumption with CHD risk and quality the dose-response relationship between them.Methods: Relevant prospective studies were identified by a search of PubMed, Embase and Web of Science databases to July 2014. A random-effects model was used to calculate the pooled relative risk (RR) and 95% confidence intervals (CI).Results: Twenty-three studies involving 937,665 participants and 18,047 patients with CHD were included. Compared with the lowest consumption levels of total fruit and vegetable, fruit and vegetable, the RR of CHD was 0.84 (95% CI, 0.79-0.90), 0.86 (95% CI, 0.82-0.91), 0.87 (95% CI, 0.81-0.93), respectively. The dose-response analysis indicated that, the RR of CHD was 0.88 (95% CI: 0.85-0.91) per 477 g/day of total fruit and vegetable consumption, 0.84 (95% CI: 0.75-0.93) per 300 g/day of fruit intake and 0.82 (95% CI: 0.73-0.92) per 400 g/day of vegetable consumption. A nonlinear association of CHD risk with fruit or vegetable consumption separately was found (P for nonlinearity