Role of the precentral gyrus of the insula in complex articulation
Role of the precentral gyrus of the insula in complex articulation
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DOI：
10.1016/j.cortex.2010.07.001
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发表时间：
2011-07-01
期刊：
影响因子：
3.6
通讯作者：
Dronkers, Nina F.
中科院分区：
文献类型：
--
作者：
Baldo, Juliana V.;Wilkins, David P.;Dronkers, Nina F.
以往的研究表明，左侧前脑岛，特别是岛叶中央前上回(SPGI)是协调复杂关节运动的关键脑区。然而，之前的研究还没有确定哪些发音因素具体依赖于这个大脑区域。在目前的研究中，33名患有不同程度言语障碍的左半球中风患者被要求多次重复单个单词，这些单词在三个不同的维度上有所不同：音节数量、发音移动的程度(即辅音发音位置之间的变化)和有/没有声母簇。SPGI在三种情况下的表现中的作用是通过基于体素的病变症状映射(VLSM)来确定的，VLSM是一种用于病变分析的统计方法，不需要根据病变位置或症状特征来区分患者。相反，输入连续的性能数据，以及在归一化空间中重建的病变。根据初步分析，有足够的能力发现SPGI中的差异，这是我们预测的重点。我们发现，在所有三种情况下，SPGI对发音任务的成绩都是至关重要的，即当单词是多音节的、需要高度旅行的时候，或者涉及到一个声母簇时。作为对照，我们还生成了一个VLSM映射，用于以最小的发音复杂性(即，没有初始聚类的单音节单词和最小的发音变化)来发音。在这起案件中，SPGI没有牵连。目前的结果表明，左侧SPGI是复杂发音动作的音节内和音节间协调的关键区域，在语音命令的末期执行之前。由Elsevier Srl出版。
Previous research has suggested that the left anterior insula, specifically the superior precentral gyrus of the insula (SPGI), is a critical brain region for the coordination of complex articulatory movements. However, previous studies have not determined which articulatory factors are specifically dependent on this brain region. In the current study, 33 left hemisphere stroke patients with varying degrees of speech impairment were asked to perform multiple repetitions of single words that varied along three separate dimensions: number of syllables, degree of articulatory travel (i.e., change between places of articulation for consonants), and presence/absence of an initial consonant cluster. The role of the SPGI in performance across the three conditions was determined using voxel-based lesion symptom mapping (VLSM), a statistical approach to lesion analysis that does not require separating patients based on lesion site or symptom profile. Rather, continuous performance data are entered, along with lesions reconstructed in normalized space. Based on preliminary analyses, there was adequate power to detect differences in the SPGI, which was the focus of our predictions. We found that the SPGI as critical for performance on the articulation task across all three conditions, namely, when words were multi-syllabic, required a high degree of travel, or involved an initial consonant cluster. As a control, we also generated a VLSM map for articulation of words with minimal articulatory complexity (i.e., single-syllable words with no initial cluster and a minimal change in place of articulation). In this case, the SPGI was not implicated. The current results suggest that the left SPGI is a critical area for intra- and inter-syllabic coordination of complex articulatory movements, prior to end-stage execution of speech commands. Published by Elsevier Srl.