SODIUM-CHANNELS IN DENDRITES OF RAT CORTICAL PYRAMIDAL NEURONS
SODIUM-CHANNELS IN DENDRITES OF RAT CORTICAL PYRAMIDAL NEURONS
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DOI：
10.1073/pnas.86.7.2473
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发表时间：
1989-04-01
影响因子：
11.1
通讯作者：
PRINCE, DA
中科院分区：
文献类型：
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作者：
HUGUENARD, JR;HAMILL, OP;PRINCE, DA
浦肯野细胞和海马锥体细胞树突的电压依赖性在这些神经元的整合能力中起着重要作用。相比之下，新皮质锥体细胞树突状细胞膜的特性更难评估。突触输入点附近的树突电导对这些神经元的输入-输出特性有重要影响。在这里报道的实验中，我们获得了直接的证据，电压依赖性Na+通道的存在，新皮层神经元的树突通过使用细胞贴附补丁和全细胞记录从急性分离的大鼠新皮层锥体细胞。树突和体细胞电流的定性和定量特性是不可否认的。与Na+电流相比，索马和初级顶树突可视为一个相对均匀的室。在成熟神经元树突上类似的树突Na+电流将在确定这些皮层单位的整合特性中发挥重要作用。
The voltage-dependent properties that have been directly demonstrated in Purkinje cell and hippocampal pyramidal cell dendrites play an important role in the integrative capacities of these neurons. By contrast, the properties of neocortical pyramidal cell dendritic membranes have been more difficult to assess. Active dendritic conductances near sites of synaptic input would have an important effect on the input-output characteristics of these neurons. In the experiments reported here, we obtained direct evidence for the existence of voltage-dependent Na+ channels on the dendrites of neocortical neurons by using cell-attached patch and whole cell recordings from acutely isolated rat neocortical pyramidal cells. The qualitative and quantitative properties of dendritic and somatic currents were indistinguisable. Insofar as Na+ currents are concerned, the soma and primary apical dendrite can be considered as one relatively uniform compartment. Similar dendritic Na+ currents on dendrites in mature neurons would play an important role in determining the integrative properties of these cortical units.