What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
What's the relative risk? A method of correcting the odds ratio in cohort studies of common outcomes
复制标题
DOI：
10.1001/jama.280.19.1690
复制
发表时间：
1998-11-18
影响因子：
120.7
通讯作者：
Yu, KF
中科院分区：
文献类型：
--
作者：
Zhang, J;Yu, KF
Logistic回归在队列研究和临床试验中经常使用。当感兴趣的结果的发生率在研究人群中很常见(>；10%)时，由Logistic回归得出的调整后的优势比不再能接近风险比。结果越频繁，当风险比大于1时，赔率比越高，当风险比小于1时，赔率比越低。我们提出了一种简单的方法，从调整后的赔率比近似风险比，并得出更好地代表真实相对风险的关联或治疗效果的估计。
Logistic regression is used frequently in cohort studies and clinical trials. When the incidence of an outcome of interest is common in the study population (>10%), the adjusted odds ratio derived from the logistic regression can no longer approximate the risk ratio. The more frequent the outcome, the more the odds ratio overestimates the risk ratio when it is more than 1 or underestimates it when it is less than 1. We propose a simple method to approximate a risk ratio from the adjusted odds ratio and derive an estimate of an association or treatment effect that better represents the true relative risk.