Determinants of high blood pressure in salt-deprived renal hypertensive rats: role of changes in plasma volume, extracellular fluid volume and plasma angiotensin II.
Determinants of high blood pressure in salt-deprived renal hypertensive rats: role of changes in plasma volume, extracellular fluid volume and plasma angiotensin II.
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缺盐肾高血压大鼠高血压的决定因素：血浆容量、细胞外液容量和血浆血管紧张素 II 变化的作用。
DOI：
10.1042/cs0550081
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
A. Mourant
中科院分区：
文献类型：
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作者：
A. Mourant
1.留置主动脉和右心房插管的大鼠在肾动脉缩窄加对侧肾切除前后维持无钠饮食。对照组动物接受相同的方案，只是使用了非缩窄性夹子。2.缺盐动物的血浆容量低于自由获取钠的动物先前测定的数值。夹闭后高血压动物的血浆容量增加。仅在术后第二天，正常血压动物和高血压动物的细胞外液容量均有增加。3.夹闭前和对侧肾切除前血浆血管紧张素Ⅱ水平均高于正常。术后14天血管紧张素II浓度降至正常，试验组和对照组之间无明显差异。4.认为夹闭后血压升高可能部分是由于血浆容量的增加所致。然而，这些结果强烈地表明，其他肾脏机制可能具有重要的致病作用。
1. Rats with indwelling aortic and right atrial cannulae were maintained on a sodium-free diet before and after renal arterial constriction combined with contralateral nephrectomy. Control animals underwent the same protocol except that non-constricting clips were used. 2. Plasma volumes in the salt-deprived animals were lower than previously determined values in animals with free access to sodium. After clipping plasma volume increased in the hypertensive animals. Extracellular fluid volume was increased equally in both normotensive and hypertensive animals on the second postoperative day only. 3. Before clipping and contralateral nephrectomy plasma angiotensin II values were higher than normal. After the operation angiotensin II concentrations fell to normal over a period of 14 days without significant differences between experimental and control groups. 4. It is concluded that high blood pressure after clipping may be in part maintained by increases in plasma volume. However, the results strongly suggest that other renal mechanisms are likely to be of major pathogenic importance.