URINARY TRYPSIN-INHIBITOR SUPPRESSES PREMATURE CERVICAL RIPENING
URINARY TRYPSIN-INHIBITOR SUPPRESSES PREMATURE CERVICAL RIPENING
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DOI：
10.1016/0028-2243(95)02087-9
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发表时间：
1995-06-01
影响因子：
2.6
通讯作者：
TERAO, T
中科院分区：
文献类型：
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作者：
KANAYAMA, N;ELMARADNY, E;TERAO, T
来自胎儿的未知信号被认为与分娩的开始有关。我们最近发现，尿胰蛋白酶抑制剂（UTI）从胎儿尿抑制子宫肌肉收缩。目的：本研究旨在阐明UTI在抑制宫颈成熟中的作用机制。研究设计：未怀孕和未怀孕的家兔分别用含1000u （400 μ g）的UTI栓剂和未使用栓剂预处理3天，再用含100ng白介素-8 （IL-8）的阴道栓剂治疗2天。结果：IL-8诱导兔颈部软化和扩张。相反，UTI抑制IL-8诱导的颈椎软化和扩张。IL-8可提高宫颈组织的水分含量、胶原蛋白含量、中性粒细胞计数、弹性酶活性和胶原酶活性，但IL-8对UTI的影响不明显。结论：UTI可抑制IL-8诱导的宫颈成熟。
Unknown signals from the fetus are thought to be involved in the onset of parturition. We recently discovered that urinary trypsin inhibitor (UTI) from fetal urine inhibits uterine muscle contraction. Objectives: The aim of this research was to elucidate the mechanism of action of UTI in suppressing cervical maturation. Study design: Non-pregnant and pregnant rabbits pretreated with and without UTI suppositories containing 1000 U (400 mu g) for 3 days were treated for 2 days with vaginal suppositories containing 100 ng of interleukin-8 (IL-8). Results: IL-8 induced softening and dilatation of the rabbit cervices. In contrast UTI inhibited IL-8 induced cervical softening and dilatation. Water content, collagen content, neutrophil counts, elastase activity and collagenase activity of the cervix were increased by IL-8, but they did not increase by IL-8 with UTI. Conclusion: These results suggest that UTI inhibits cervical maturation induced by IL-8.