Performance of the 2015 International Task Force Consensus Statement Risk Stratification Algorithm for Implantable Cardioverter-Defibrillator Placement in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Performance of the 2015 International Task Force Consensus Statement Risk Stratification Algorithm for Implantable Cardioverter-Defibrillator Placement in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
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DOI：
10.1161/circep.117.005593
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发表时间：
2018-02-01
影响因子：
8.4
通讯作者：
James, Cynthia A.
中科院分区：
文献类型：
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作者：
Orgeron, Gabriela M.;te Riele, Anneline;James, Cynthia A.
背景：室性心律失常是致心律失常性右心室发育不良/心肌病的一种令人担忧的并发症。 2015 年，国际工作组共识声明提出了一种用于治疗致心律失常性右心室发育不良/心肌病的植入式心脏复律除颤器放置的风险分层算法。方法和结果：为了评估该算法的性能，根据算法在基线时将 365 名心律失常性右心室发育不良/心肌病患者分为 I 类、IIa 类、IIb 类或 III 类适应症。主要结局是随访期间无持续性室性心律失常（VT/VF）的生存。心室颤动/扑动周期长度10%/年的发生率I级； 15.5 [置信区间 11.1-21.6] 与 1% 至 10%/年（IIa 类）。此外，该算法没有区分 I 类和 IIa 类患者的无室颤/扑动生存率 (P=0.97) 或 I 类和 IIa 类一级预防患者的 VT/VF 生存率 (P=0.22)。添加动态心电图结果 (
BACKGROUND: Ventricular arrhythmias are a feared complication of arrhythmogenic right ventricular dysplasia/cardiomyopathy. In 2015, an International Task Force Consensus Statement proposed a risk stratification algorithm for implantable cardioverter-defibrillator placement in arrhythmogenic right ventricular dysplasia/cardiomyopathy.METHODS AND RESULTS: To evaluate performance of the algorithm, 365 arrhythmogenic right ventricular dysplasia/cardiomyopathy patients were classified as having a Class I, IIa, IIb, or III indication per the algorithm at baseline. Survival free from sustained ventricular arrhythmia (VT/VF) in follow-up was the primary outcome. Incidence of ventricular fibrillation/flutter cycle length 10%/year Class I; 15.5 [confidence interval 11.1-21.6] versus 1% to 10%/year Class IIa). In addition, the algorithm did not differentiate survival free from ventricular fibrillation/flutter between Class I and IIa patients (P=0.97) or for VT/VF in Class I and IIa primary prevention patients (P=0.22). Adding Holter results (