Neuromuscular disorders in severe acute respiratory syndrome
Neuromuscular disorders in severe acute respiratory syndrome
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DOI：
10.1001/archneur.61.11.1669
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发表时间：
2004-11-01
影响因子：
--
通讯作者：
Chang, YC
中科院分区：
文献类型：
--
作者：
Tsai, LK;Hsieh, ST;Chang, YC
目的：描述和澄清可能严重急性呼吸综合征（SARS）患者的神经肌肉疾病。设计：病例系列，随访范围为3周至2个月。设置：国立台湾大学医院，台北。患者：我们调查了4例SARS患者伴随神经肌肉问题。SARS的诊断是基于血清冠状病毒抗体的显示。临床表现，实验室检查结果，电生理检查结果，和后续conditions.Results：患者发生神经肌肉问题约3周后，SARS。2名女性出现运动主导型周围神经疾病。一名男子发生肌病，第三名妇女发生神经病变和肌病。2例神经病患者脑脊液蛋白质含量正常，无白细胞增多和SARS冠状病毒抗体。两名肌病患者血清肌酸激酶水平升高。一个快速的临床和电生理改善是明显的，在后续的检查，预后良好。结论：SARS患者的神经肌肉问题被认为是危重病多发性神经病或肌病，可能共存。进一步的病理学和微生物学研究是必要的，以确定SARS冠状病毒和神经肌肉问题之间的关系。
Objective: To delineate and clarify neuromuscular disorders in patients with probable severe acute respiratory syndrome (SARS).Design: Case series with follow-up ranging from 3 weeks to 2 months.Setting: National Taiwan University Hospital, Taipei.Patients: We investigated 4 patients with SARS who had concomitant neuromuscular problems. A diagnosis of SARS was based on the demonstration of serum coronavirus antibodies. Clinical presentations, laboratory results, electrophysiologic findings, and follow-up conditions were determined.Results: Patients developed neuromuscular problems approximately 3 weeks after the onset of SARS. Two women experienced motor-predominant peripheral nerve disorders. A man developed myopathy and a third woman experienced neuropathy and myopathy. Cerebrospinal fluid obtained from 2 patients with neuropathy disclosed normal protein content and the absence of pleocytosis and SARS coronavirus antibodies. Both patients with myopathy had elevated serum creatine kinase levels. A rapid clinical and electrophysiologic improvement was evident during follow-up examinations, with a good prognosis.Conclusions: The neuromuscular problems in patients with SARS are considered to be critical-illness polyneuropathy or myopathy, possibly coexistent. Further pathological and microbiological studies are necessary to determine the relationship between SARS coronavirus and neuromuscular problems.