The mechanistic rationale in support of dietary cancer prevention.
The mechanistic rationale in support of dietary cancer prevention.
复制标题
支持饮食癌症预防的机制原理。
作者：
D. Rose
机理研究是饮食癌症预防试验的重要组成部分。对于乳腺癌和前列腺癌，减少omega-6脂肪酸的低脂肪饮食可能被证明是有效的，这不仅是因为性类固醇激素的相关减少，也是二十烷类化合物生物合成改变的结果。一级和二级预防的最佳方法可能是改变饮食，结合一种或多种以药物为基础的化学预防药物。乳腺癌或前列腺癌患者适合作为二级预防手段进行饮食干预。
Mechanistic studies are an essential component of dietary cancer prevention trials. In breast and prostate cancer, a low-fat diet with a reduction in omega-6 fatty acid may prove effective, not only because of related decreases in sex steroid hormones, but as a result of altered eicosanoid biosynthesis. An optimal approach to primary and secondary prevention is likely to be a dietary change combined with one or more pharmacologically based chemopreventive agents. Patients with in situ carcinoma of the breast or prostate are candidates for dietary intervention as a means of secondary prevention.