Chemoprevention of OH-BBN-induced bladder cancer in mice by piroxicam.
Chemoprevention of OH-BBN-induced bladder cancer in mice by piroxicam.
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吡罗昔康对小鼠 OH-BBN 诱导的膀胱癌进行化学预防。
DOI：
10.1093/carcin/14.7.1487
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发表时间：
1993
期刊：
影响因子：
4.7
通讯作者：
Sigman,CC
中科院分区：
文献类型：
--
作者：
Moon,RC;Kelloff,GJ;Detrisac,CJ;Steele,VE;Thomas,CF;Sigman,CC
吡罗昔康抑制N-丁基-N-（4-羟丁基）-亚硝胺诱发小鼠膀胱移行细胞癌。与致癌物对照组相比，15 mg吡罗昔康/kg饲料的肿瘤发生率降低了82%（P< 0.0001）。吡罗昔康30 mg/kg时，肿瘤发生率降低70%（P< 0.001）。较高剂量水平的结果表明，吡罗昔康也可能轻微抑制侵袭。2-二氟甲基鸟氨酸（DFMO）或全反式-N-（4-羟基苯基）视黄酰胺（4-HPR）或两种药物联合治疗均未改善吡罗昔康的化学预防潜力。然而，30 mg吡罗昔康/kg、1200 mg DFMO/kg和313 mg 4-HPR/kg饲料的三种药剂组合是高度有效的。与致癌物对照组相比，肿瘤发生率降低91%（P< 0.0001）。不幸的是，与致癌物对照相比，接受药物组合的小鼠的存活率和体重增加显著降低，这在一定程度上损害了高疗效。
Piroxicam inhibited induction of transitional cell carcinoma in mouse urinary bladder byN-butyl-N-(4-hydroxybutyl)-nitrosamine. At 15 mg piroxicam/kg diet, tumor incidence was reduced 82% (P< 0.0001) compared with carcinogen controls. At 30 mg piroxicam/kg diet, tumor incidence was reduced 70% (P< 0.001). Results at the higher dose level suggested that piroxicam also may have inhibited invasion slightly. Combination treatment with 2-difluoromethylornithine (DFMO) or all-trans-N-(4-hydroxyphenyl)retin-amide (4-HPR) or both agents did not improve the chemopreventive potential of piroxicam. However, the three-agent combination of 30 mg piroxicam/kg, 1200 mg DFMO/kg and 313 mg 4-HPR/kg diet was highly effective. Tumor incidence was reduced 91% (P< 0.0001) compared with carcinogen controls. Unfortunately, the high efficacy was somewhat compromised by a significant decrease in survival and body weight gain in mice receiving the combination of agents compared with the carcinogen control.