High-Fidelity Physical Organ Simulators: From Artificial to Bio-Hybrid Solutions
High-Fidelity Physical Organ Simulators: From Artificial to Bio-Hybrid Solutions
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DOI：
10.1109/tmrb.2021.3063808
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发表时间：
2021-05-01
期刊：
影响因子：
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通讯作者：
Roche, E. T.
中科院分区：
文献类型：
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作者：
Maglio, S.;Park, C.;Roche, E. T.
在过去的十年中，人们对医疗应用的高保真模拟越来越感兴趣，导致人们对具有真实人体器官表现的物理器官模拟器进行了大量的研究工作。由于这是一个相对年轻的研究领域，本次综述旨在深入了解高保真物理器官模拟器的最新技术水平，这些模拟器可用于培训目的、教育工具、生物力学研究和临床前设备测试。由于各种模拟器缺乏明确的定义和分类，我们根据其应用背景下目标器官的解剖结构、材料特性和生理行为的表征程度来描述高保真物理器官模拟器。我们重点介绍使用合成材料的静态器官模拟器的传统方法，以及动态器官模拟器的多种方法，包括软机器人、离体和生物混合策略，以满足对逼真的拟人器官模型不断增长的需求。最后，我们讨论高保真物理器官模拟器领域的挑战和潜在的未来途径。
Over the past decade, there has been growing interest in high-fidelity simulation for medical applications leading to huge research efforts towards physical organ simulators with realistic representations of human organs. As this is a relatively young research field, this review aims to provide an insight into the current state of the art in high-fidelity physical organ simulators that are used for training purposes, as educational tools, for biomechanical studies, and for preclinical device testing. Motivated by a paucity of clear definitions and categorization of various simulators, we describe high-fidelity physical organ simulators in terms of their degree of representation of the anatomy, material properties, and physiological behavior of the target organs in the context of their applications. We highlight the traditional approaches for static organ simulators using synthetic materials, and diverse approaches for dynamic organ simulators including soft robotic, ex vivo, and biohybrid strategies to meet the ever-increasing demand for realistic anthropomorphic organ models. Finally, we discuss challenges and potential future avenues in the field of high-fidelity physical organ simulators.