Production of erythroid cells from human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPS)
Production of erythroid cells from human embryonic stem cells (hESC) and human induced pluripotent stem cells (hiPS)
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DOI：
10.1016/j.tracli.2010.05.005
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发表时间：
2010-09-01
影响因子：
1.7
通讯作者：
Anstee, D. J.
中科院分区：
文献类型：
--
作者：
Anstee, D. J.
红系祖细胞可以从人胚胎干细胞（hESC）或人诱导多能干细胞（hiPS）离体产生。能够从人胚胎干细胞或人诱导多能干细胞产生成熟功能性红细胞的实验室规模培养条件的开发将为制造治疗量的红细胞并由此制造新的临床输血产品打开可能性。来自人胚胎干细胞的红细胞揭示了需要更好地理解原始红细胞生成向确定的胎儿和成人红细胞生成转变的过程以及驱动红细胞成熟的因素。出版社：Elsevier Masson SAS
Erythroid progenitors can he generated ex vivo from human embryonic stem cells (hESC) or human Induced pluripotent stem cells (hiPS) Development of laboratory scale culture conditions capable of generating mature functional erythrocytes from human embryonic stem cells or human induced pluripotent stem cells would open the possibility for manufacture of therapeutic quantities of red cells and thereby new clinical transfusion products Current attempts to produce erythrocytes from human embryonic stem cells reveal the need for greater understanding of the process whereby primitive erythropoiesis switches to definitive fetal and adult erythropoiesis and the factors driving erythrocyte maturation Studies with human embryonic stem cells have already yielded encouraging results but functional mature biconcave erythrocytes have yet to he generated from these cells (C) 2010 Published by Elsevier Masson SAS