Astroglia, Glutamatergic Transmission and Psychiatric Diseases.
Astroglia, Glutamatergic Transmission and Psychiatric Diseases.
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DOI：
10.1007/978-3-319-45096-4_12
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发表时间：
2016
影响因子：
--
通讯作者：
A. Verkhratsky;L. Steardo;Liang Peng;V. Parpura
中科院分区：
文献类型：
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作者：
A. Verkhratsky;L. Steardo;Liang Peng;V. Parpura
星形胶质细胞是中枢神经系统的主要稳态细胞。它们通过从细胞外空间清除谷氨酸和向神经元提供谷氨酰胺来调节谷氨酸能传递。谷氨酸能传递通常被认为是显着受损的情况下，所有主要的神经精神疾病。在大多数这些神经精神疾病中，星形胶质细胞显示出变性和萎缩的迹象，这可能会转化为降低的稳态能力。星形胶质细胞谷氨酸摄取/释放和谷氨酸稳态在所有形式的主要精神疾病中受到影响，并且代表了神经传递失衡、异常连接体和神经元网络信息处理的整体失败的共同机制，这些机制是神经精神疾病发病机制的基础。
Astrocytes are primary homeostatic cells of the central nervous system. They regulate glutamatergic transmission through the removal of glutamate from the extracellular space and by supplying neurons with glutamine. Glutamatergic transmission is generally believed to be significantly impaired in the contexts of all major neuropsychiatric diseases. In most of these neuropsychiatric diseases, astrocytes show signs of degeneration and atrophy, which is likely to be translated into reduced homeostatic capabilities. Astroglial glutamate uptake/release and glutamate homeostasis are affected in all forms of major psychiatric disorders and represent a common mechanism underlying neurotransmission disbalance, aberrant connectome and overall failure on information processing by neuronal networks, which underlie pathogenesis of neuropsychiatric diseases.