The rsl2255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians
The rsl2255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians
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DOI：
10.1016/j.metabol.2007.04.012
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发表时间：
2007-09-01
影响因子：
9.8
通讯作者：
Mohan, Viswanathan
中科院分区：
文献类型：
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作者：
Bodhini, Dhanasekaran;Radha, Venkatesan;Mohan, Viswanathan
采用聚合酶链反应-限制性片段长度多态性测定法对金奈城乡流行病学研究中选取的1038名正常耐糖受试者和1031名2型糖尿病受试者进行基因分型，探讨转录因子7样2（TCF7L2）基因rs12255372（G/T）和rs7903146（C/T）多态性与2型糖尿病的关系亚洲印第安人的健康状况。与正常耐糖受试者相比，rs12255372(G/T) 和 rs7903146(C/T) 多态性的“T”等位基因频率在糖尿病受试者中显着较高（23% 和 33%）（19% 和 28%；分别为 P = .001 和 P = .0001）。 rs12255372(G/T) 多态性的 Logistic 回归分析显示，TT 基因型的比值比（根据年龄、性别和体重指数调整）为 1.56（95% 置信区间 [CI]，1.03-2.37；P = .034），为 1.29（95% CI，1.06-1.58；P = .01 1） TG 基因型与 GG 基因型相比。与 CC 基因型相比，rs7903146(C/T) 多态性的 TT 和 TC 基因型的调整优势比分别为 1.50 (95% CI, 1.08-2.08; P = .013) 和 1.44 (95% CI, 1.18-1.76; P = .0003)。具有 rs12255372(G/T) TT 基因型的正常耐糖受试者的 2 小时血浆葡萄糖水平（平均值 +/- SD，6.1 +/- 1.4 mmol/L）显着高于具有 GG 基因型的受试者（5.6 +/- 1.0 mmol/L，P = .011）。具有 rs7903146(C/T) 多态性 TT 基因型的正常耐糖受试者的 2 小时血浆葡萄糖水平（平均值 +/- SD，6.0 +/- 1.3 mmol/L）显着高于具有 CC 基因型的受试者（5.6 +/- 1.0 mmol/L，P = .004）。总之，TCF7L2基因rs12255372(G/T)和rs7903146(C/T)多态性的T等位基因赋予亚洲印度人2型糖尿病的易感性。 (C) 2007 Elsevier Inc. 保留所有权利。
One thousand thirty-eight normal glucose-tolerant and 1031 type 2 diabetic subjects selected from the Chennai Urban Rural Epidemiology Study were genotyped using polymerase chain reaction-restriction fragment length polymorphism assay to investigate the association of rs12255372(G/T) and rs7903146(C/T) polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene with type 2 diabetes mellitus in Asian Indians. The frequency of the "T" allele of both rs12255372(G/T) and rs7903146(C/T) polymorphisms was significantly higher in diabetic subjects (23% and 33%) compared to that in normal glucose-tolerant subjects (19% and 28%; P = .001 and P = .0001, respectively). Logistic regression analysis of the rs12255372(G/T) polymorphism showed that the odds ratio (adjusted for age, sex, and body mass index) was 1.56 (95% confidence interval [CI], 1.03-2.37; P = .034) for the TT genotype and 1.29 (95% CI, 1.06-1.58; P = .01 1) for the TG genotype when compared with the GG genotype. Adjusted odds ratios for the TT and TC genotypes of the rs7903146(C/T) polymorphism were found to be 1.50 (95% CI, 1.08-2.08; P = .013) and 1.44 (95% CI, 1.18-1.76; P = .0003), respectively, compared with the CC genotype. Normal glucose-tolerant subjects with the TT genotype of rs12255372(G/T) had significantly higher 2-hour plasma glucose levels (mean +/- SD, 6.1 +/- 1.4 mmol/L) than those with tile GG genotype (5.6 +/- 1.0 mmol/L, P = .011). Normal glucose-tolerant subjects with the TT genotype of rs7903146(C/T) polymorphism had significantly higher 2-hour plasma glucose levels (mean +/- SD, 6.0 +/- 1.3 mmol/L) than those with the CC genotype (5.6 +/- 1.0 mmol/L, P = .004). In conclusion, the T allele of the rs12255372(G/T) and rs7903146(C/T) polymorphisms of TCF7L2 gene confer susceptibility to type 2 diabetes mellitus in Asian Indians. (C) 2007 Elsevier Inc. All rights reserved.