Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset.
Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset.
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DOI：
10.3410/b2-55
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发表时间：
2010-07-22
期刊：
影响因子：
--
通讯作者：
Shah JV
中科院分区：
文献类型：
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作者：
Hardwick KG;Shah JV
纺锤体检查点在存在有缺陷的动粒-微管连接的情况下推迟了后期的开始。这种延迟可能只持续几分钟或几个小时，但在所有染色体达到双向后不久，就会出现显著的同步后期。我们开始了解参与沉默纺锤体检查点信号和随后激活后期促进复合体的途径。在这里，我们回顾了最新的进展，在我们的理解，调控这一关键的细胞周期转变的分子机制。
The spindle checkpoint delays anaphase onset in the presence of defective kinetochore-microtubule attachments. Such delays can last for just a few minutes or several hours, but very shortly after all chromosomes achieve bi-orientation, a remarkably synchronous anaphase ensues. We are beginning to understand the pathways involved in silencing spindle checkpoint signals and subsequent activation of the anaphase-promoting complex. Here, we review recent advances made in our understanding of the molecular mechanisms regulating this critical cell cycle transition.