Pancreatic polypeptide in dorsal vagal complex stimulates gastric acid secretion and motility in rats.
Pancreatic polypeptide in dorsal vagal complex stimulates gastric acid secretion and motility in rats.
复制标题
背侧迷走神经复合体中的胰多肽刺激大鼠胃酸分泌和胃动力。
DOI：
10.1152/ajpgi.1993.265.6.g1169
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Rogers,RC
中科院分区：
文献类型：
--
作者：
McTigue,DM;Edwards,NK;Rogers,RC
胰腺多肽(PP)是一种胰腺激素，近年来在迷走神经背侧复合体(DVC)的背内侧区域发现了高浓度的胰多肽受体。我们推测，胃酸分泌和运动，消化功能受到迷走神经反射的强烈影响，将PP直接应用于迷走神经感觉运动整合区域。乌拉坦麻醉大鼠作胃窦运动记录或胃酸输出滴定分析后，将磷酸盐缓冲液或不同剂量磷酸盐缓冲液中的PP注入DVC内侧。DVC内注射PP后，胃酸分泌和胃窦运动显著、持久且呈剂量依赖性增加。这些胃反应可被双侧颈迷走神经切断和阿托品阻断，提示延髓内PP刺激迷走神经胆碱能通路，从而增强胃功能。由于PP不是在中枢神经系统内合成的，这些结果指出了一种新的机制，通过这种机制，消化道可以调节自己的自主神经控制：对脑干内迷走神经反射回路的直接体液作用。
High concentrations of receptors for pancreatic polypeptide (PP), a pancreatic hormone, were recently discovered in the dorsomedial region of the dorsal vagal complex (DVC). We hypothesized that gastric acid secretion and motility, digestive functions strongly influenced by vagovagal reflexes organized within the DVC, would be affected by PP applied directly to this vagal sensorimotor integration area. After urethan-anesthetized rats were prepared for antral motility recording or titrometric analysis of gastric acid output, phosphate-buffered saline or various doses of PP in phosphate-buffered saline were micropressure injected into the medial DVC. Injections of PP into the DVC produced significant, long-lasting, and dose-dependent increases in gastric acid secretion and antral motility. These gastric responses were blocked by bilateral cervical vagotomy and by atropine, suggesting that intramedullary PP stimulates vagal cholinergic pathways, resulting in enhanced gastric functions. Because PP is not synthesized within the central nervous system, these results point to a new mechanism whereby the digestive tract may modulate its own autonomic control: direct humoral action on vagovagal reflex circuits within the brain stem.