The European collaborative study on mosaicism in chorionic villus sampling: Data from 1986 to 1987
The European collaborative study on mosaicism in chorionic villus sampling: Data from 1986 to 1987
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欧洲关于绒毛膜绒毛取样嵌合现象的合作研究：1986年至1987年的数据
DOI：
10.1002/pd.1970090807
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发表时间：
1989
影响因子：
3
通讯作者：
M. Mikkelsen
中科院分区：
文献类型：
--
作者：
L. Vejerslev;M. Mikkelsen
1986年和1987年共获得11855份诊断绒毛样本的数据是由36个欧洲细胞遗传学中心填写的问卷汇编而成。141例报告嵌合体。24例患者行细胞遗传学检查后行人工流产术。在9例马赛克妊娠中观察到自然流产，这一比率与观察到的CVS的总发生率没有显著差异。直接分析/短期培养的分析中有1.2%发现马赛克现象，而长期培养后发现的这一比例为0.6%。在141例中有99例发现了胎儿非嵌合体的证据。在妊娠早期的CVS中发现嵌合体，应该总是引起进一步的分析，最好是在羊膜穿刺术之后，以证实可疑的胎儿染色体异常。
Data on a total of 11 855 diagnostic chorionic villus samples obtained in the years 1986 and 1987 were compiled from a questionnaire filled in by 36 European cytogenetic centres. Mosaicism was reported in 141 cases. The cytogenetic findings were followed by induced abortion in 24 cases. Spontaneous abortion was observed in nine mosaic pregnancies, a rate not significantly different from that observed for CVS in total. Mosaicism was found in 1.2 per cent of analyses by direct analysis/short‐term culture, in contrast to the 0.6 per cent found after long‐term culture. Evidence for fetal non‐mosaicism was found in 99 of the 141 cases. The finding of mosaicism in first‐trimester CVS should always elicit further analyses, preferably after amniocentesis, to substantiate the suspected fetal chromosome aberration.
影响因子：
9.8
作者：
Martin,AO;Simpson,JL;Rosinsky,BJ;Elias,S
通讯作者：
Elias,S