Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats.
Bone marrow mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke in type 2 diabetic rats.
复制标题
骨髓间充质干细胞条件培养基增强 2 型糖尿病大鼠中风后的血管重塑。
DOI：
10.1016/j.neulet.2017.02.040
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发表时间：
2017
影响因子：
2.5
通讯作者：
Ye Xinchun
中科院分区：
文献类型：
--
作者：
Xiang Jie;Hu Jinxia;Shen Tong;Liu Bin;Hua Fang;Zan Kun;Zu Jie;Cui Guiyun;Ye Xinchun
我们以前的研究发现，干细胞条件培养基（CM）促进非糖尿病患者中风后的功能恢复。然而，在2型糖尿病（T2 DM）大鼠中风后，骨髓基质细胞条件培养基（BMSCs-CM）治疗是否改善功能结果仍不清楚。诱导T2 DM大鼠并使其经历中风，然后用或不用BMSCs-CM治疗。观察两组患者的功能转归、血脑屏障（BBB）通透性、血管生成素（Ang）1和酪氨酸激酶（Tie）2的表达。结果显示，BMSCs-CM治疗后2型糖尿病脑卒中患者的功能结局明显改善，血脑屏障渗漏减少，血管生成素1和Tie 2的表达也发生了变化。结论：BMSCs-CM治疗脑卒中后缺血脑组织Ang 1和Tie 2表达增强可能有助于改善2型糖尿病大鼠脑卒中后的功能恢复。
Our previous studies have found that stem cells conditioned medium (CM) facilitated functional recovery after stroke in non-diabetics. However, whether bone marrow stromal cells conditioned medium (BMSCs-CM) treatment after stroke in type 2 diabetic (T2DM) rats improve functional outcomes remains unclear. T2DM rats were induced and subjected to stroke then treated with or without BMSCs-CM. Functional outcomes and blood-brain barrier (BBB) leakage were performed, the expression of Angiopoietin (Ang) 1 and tyrosine kinase (Tie) 2 were also assessed. Our results showed that BMSCs-CM treatment significantly improved functional outcomes, decreased BBB leakage and the expression of Ang1 and Tie2 were also changed after BMSCs-CM treatment in type 2 diabetes after stroke. In conclusion, enhanced expression of Ang1 and Tie2 in ischemic brain after BMSCs-CM treatment of stroke may contribute to the improved functional recovery after stroke in type 2 diabetic rats.