CIZ1 promoted the growth and migration of gallbladder cancer cells
CIZ1 promoted the growth and migration of gallbladder cancer cells
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CIZ1促进胆囊癌细胞的生长和迁移
DOI：
10.1007/s13277-014-2876-y
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发表时间：
2015-04-01
期刊：
影响因子：
--
通讯作者：
Liu, Houbao
中科院分区：
文献类型：
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作者：
Zhang, Dexiang;Wang, Yueqi;Liu, Houbao
胆囊癌（GBC）是胃肠道恶性肿瘤中最常见、最具侵袭性的疾病之一，其发病机制尚不清楚。CIZ 1（Cip 1 interacting zinc finger protein 1）是p21 Cip 1/Waf 1的结合伴侣，近年来发现其与肿瘤的发生有关。然而，CIZ 1在GBC进展中的表达模式和生物学功能尚未完全了解。在这项研究中，发现CIZ 1的表达在GBC样品中与其邻近的正常组织相比显著升高。此外，CIZ 1的过表达促进GBC细胞的生长和迁移，而敲低CIZ 1的表达抑制GBC细胞的生长、迁移和体内成瘤。从机制上讲，CIZ 1被发现与TCF 4（T细胞因子）相互作用并激活β-连环蛋白/TCF信号传导。我们的研究表明，CIZ 1在GBC的进展中发挥了致癌作用，CIZ 1可能是治疗GBC的一个有希望的靶点。
Gallbladder cancer (GBC) is one of the most common and aggressive diseases among the gastrointestinal tract malignancies, and the molecular mechanism underlying this disease remains largely unknown. CIZ1 (Cip1 interacting zinc finger protein 1), a binding partner of p21Cip1/Waf1, has been found to be involved in the tumorigenesis recently. However, the expression pattern and biological functions of CIZ1 in the progression of GBC are not fully understood. In this study, it was found that the expression of CIZ1 was significantly elevated in GBC samples compared to their adjacent normal tissues. Moreover, overexpression of CIZ1 promoted the growth and migration of GBC cells, while knocking down the expression of CIZ1 inhibited the growth, migration, and tumorigenesis of GBC cells in vitro and in vivo. Mechanistically, CIZ1 was found to interact with TCF4 (T-cell factor) and activate beta-catenin/TCF signaling. Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC.