Are Stroke Biomarkers Seeing Brain Vessels in Patients With Ischemic Stroke? A C-Reactive Protein and Homocysteine Study
Are Stroke Biomarkers Seeing Brain Vessels in Patients With Ischemic Stroke? A C-Reactive Protein and Homocysteine Study
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DOI：
10.1161/strokeaha.110.607432
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发表时间：
2011-05-01
期刊：
影响因子：
8.3
通讯作者：
Bang, Oh Young
中科院分区：
文献类型：
--
作者：
Kim, Suk Jae;Choe, Yeon Hyeon;Bang, Oh Young
背景和目的-无症状冠状动脉粥样硬化负荷（CAB）在解释卒中生物标志物结果中的意义尚不清楚。我们研究了生物标志物的值，以确定它们是否与脑动脉粥样硬化的考虑CAB。方法，我们前瞻性招募患者与非心源性栓塞缺血性脑血管疾病谁没有冠心病史。使用MRA（脑动脉）和心脏CT血管造影（冠状动脉）进行基于患者的血管评估。包括C反应蛋白和同型半胱氨酸在内的生物标志物进行了测量。颅外颈动脉狭窄与C反应蛋白最高四分位数相关（OR，2.24; 95%CI，1.04 - 4.55），而年龄是同型半胱氨酸最高四分位数的唯一预测因子（OR，1.06; 95%CI，1.02 - 1.11）。然而，考虑到CAB，CAB（>= 2个狭窄>= 50%的节段）仍然是C反应蛋白最高四分位数的唯一独立预测因素（OR，8.69; 95% CI，2.41 - 31.30）和同型半胱氨酸结论：我们的数据强调了CAB在缺血性卒中患者生物标志物研究中的重要性。（中风。2011; 42：1464 - 1468）。
Background and Purpose-The significance of asymptomatic coronary artery atherosclerosis burden (CAB) in the interpretation of stroke biomarker results is unknown. We investigated biomarker values to determine if they are related to cerebral atherosclerosis with consideration of CAB.Methods-We prospectively recruited patients with noncardioembolic ischemic cerebrovascular disease who had no history of coronary artery disease. Patient-based vascular assessment was conducted using MRA for the cerebral arteries and cardiac CT angiography for the coronary arteries. Biomarkers including the C-reactive protein and homocysteine were measured.Results-A total of 178 patients were included in the study. The extracranial carotid stenosis was associated with the highest quartile of C-reactive protein (OR, 2.24; 95% CI, 1.04-4.55), whereas age was the only predictor of the highest quartile of homocysteine (OR, 1.06; 95% CI, 1.02-1.11). However, with consideration of CAB, CAB (>= 2 segments with >= 50% stenosis) remained the only independent predictor for the highest quartile of C-reactive protein (OR, 8.69; 95% CI, 2.41-31.30) and homocysteine (OR, 11.44; 95% CI, 2.61-50.11).Conclusions-Our data emphasize the importance of CAB in biomarker studies of patients with ischemic stroke. (Stroke. 2011; 42: 1464-1468.)