BORRELIA-BURGDORFERI AND BABESIA-MICROTI - EFFICIENCY OF TRANSMISSION FROM RESERVOIRS TO VECTOR TICKS (IXODES-DAMMINI)
BORRELIA-BURGDORFERI AND BABESIA-MICROTI - EFFICIENCY OF TRANSMISSION FROM RESERVOIRS TO VECTOR TICKS (IXODES-DAMMINI)
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DOI：
10.1016/0014-4894(90)90085-q
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发表时间：
1990-01-01
影响因子：
2.1
通讯作者：
SPIELMAN, A
中科院分区：
文献类型：
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作者：
MATHER, TN;TELFORD, SR;SPIELMAN, A
在流行地区，白足鼠（Peromyscus leucopus），莱姆病螺旋体（伯氏疏螺旋体）和导致人类巴贝虫病的梨形虫（Babesioproti）的小鼠宿主，几乎普遍感染这两种病原体。偶然的是，在野外收集的蜱虫媒介-达米尼硬蜱若虫种群中，螺旋体感染的流行率几乎是巴贝斯虫感染的两倍。在实验室中，在以幼虫为食的蜱若虫中观察到类似的不成比例的感染率，无论是B。burgdorferi-或B。感染microti的小鼠。同时感染螺旋体和巴贝斯虫的小鼠，其蜱虫的螺旋体感染率也是梨浆体感染率的两倍。这些数据表明，B的获得和经食道通过的效率。burgdorferi和B.田鼠感染的差别是2倍。这种差异可能解释了在现场收集的蜱虫感染流行率以及流行地区人类螺旋体感染风险明显更大的差异。
In endemic regions, Peromyscus leucopus, the mouse reservoir of the Lyme disease spirochete (Borrelia burgdorferi) and the piroplasm causing human babesiosis (Babesia microti), is nearly universally infected with both agents. Paradoxically, spirochetal infection is nearly twice as prevalent as is babesial infection in populations of field-collected nymphal Ixodes dammini, the tick vector. In the laboratory, a similarly disproportionate rate of infection was observed among nymphal ticks, feeding as larvae, on either B. burgdorferi- or B. microti-infected mice. Ticks which fed on mice with concurrent spirochetal and babesial infections also exhibited twice the incidence of spirochetal infection over that of the piroplasm. These data suggest that the efficiency of acquisition and transstadial passage of B. burgdorferi and B. microti infection differ by a factor of two. This discrepancy may explain differences observed both in the prevalence of infection in ticks collected in the field, as well as the apparently greater risk of spirochetal infection to humans in endemic areas.