THE ISCHEMIC CASCADE - TEMPORAL SEQUENCE OF HEMODYNAMIC, ELECTROCARDIOGRAPHIC AND SYMPTOMATIC EXPRESSIONS OF ISCHEMIA
THE ISCHEMIC CASCADE - TEMPORAL SEQUENCE OF HEMODYNAMIC, ELECTROCARDIOGRAPHIC AND SYMPTOMATIC EXPRESSIONS OF ISCHEMIA
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DOI：
10.1016/0002-9149(87)90192-5
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发表时间：
1987-03-09
影响因子：
2.8
通讯作者：
KOWALCHUK, GJ
中科院分区：
文献类型：
--
作者：
NESTO, RW;KOWALCHUK, GJ
缺血性事件的发展，无论是沉默的还是痛苦的，都代表了一系列病理生理事件的累积影响。每次缺血发作都是由心肌氧供需失衡引起的，最终可能表现为心绞痛。这一系列事件可称为缺血级联。这一概念的意义在于，它将焦点从最终结果——心绞痛——转向了更基本的、潜在的病理生理因素。具体来说，这些事件包括左心室顺应性减弱、心肌收缩力下降、左心室舒张末期压升高、st段改变，偶尔还会出现心绞痛。
The development of an ischemic event, whether silent or painful, represents the cumulative impact of a sequence of pathophysiologic events. Each ischemic episode is initiated by an imbalance between myocardial oxygen supply and demand that may ultimately be manifested as angina pectoris. This sequence of events can be termed the ischemic cascade. The significance of this concept resides in the fact that it redirects the focus from the end result—angina—to the more fundamental, underlying pathophysiologic factors that precede it. Specifically, these events include diminished left ventricular compliance, decreased myocardial contractility, increased left ventricular end-diastolic pressure, ST-segment changes and, occasionally, angina pectoris.