Effects of marijuana on human natural killer cell activity.
Effects of marijuana on human natural killer cell activity.
复制标题
大麻对人类自然杀伤细胞活性的影响。
DOI：
10.1007/978-1-4684-5925-8_5
复制
发表时间：
1991
影响因子：
--
通讯作者：
Lancz,G
中科院分区：
文献类型：
--
作者：
Specter,S;Lancz,G
Marijuana and its major psychoactive component delta-9-tetrahydrocannabinol (THC) were first reported to depress various immune functions in humans as early as the mid 1970’s. (Reviewed in 1). However, these studies yielded conflicting data necessitating further investigations. Recent studies by Friedman and co-workers confirmed the immune suppressive effects of THC in mice usingin vivoandin vitroexperimental models (2–5). Klein et al. (6) reported depression of murine natural killer (NK) cell function in mice followingin vitroexposure to THC while Patel et al. (7) demonstrated inhibition of rat NK cell cytotoxicity. A re-examination of responses of human peripheral blood mononuclear cells (PBMC) following exposure to THCin vitroindicates that lymphocyte blastogenesis (8), monocyte/macrophage spreading on plastic surfaces and phagocytosis (1) and NK cell activity (9,10) all are diminished in the presence of the drug.
