A boronic acid modified binary matrix consisting of boron nitride and alpha-cyano-4-hydroxycinnamic acid for determination of cis-diols by MALDI-TOF MS
A boronic acid modified binary matrix consisting of boron nitride and alpha-cyano-4-hydroxycinnamic acid for determination of cis-diols by MALDI-TOF MS
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由氮化硼和 α-氰基-4-羟基肉桂酸组成的硼酸改性二元基质，用于通过 MALDI-TOF MS 测定顺式二醇
DOI：
10.1007/s00604-019-3711-3
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发表时间：
2019
影响因子：
5.7
通讯作者：
Feng Yu-Qi
中科院分区：
文献类型：
--
作者：
Chen Ya-Shun;Xiao Hua-Ming;Wang Tian-Qi;Yu Lei;Feng Yu-Qi
本文介绍了一种测定顺式二醇小分子化合物的MALDI-TOF质谱方法。它是基于使用由氮化硼（BN）和α-氰基-4-羟基肉桂酸组成的二元基质，该二元基质用可识别顺式二醇的（3-（吖啶-9-基氨基）苯基）硼酸衍生化试剂修饰。二元基质用于正离子模式下的解吸/电离（DI）。导致DI增强的机制进行了研究。结果表明，BN是有益的DI，因为它引起了增强的正离子模式。硼酸功能化的二元基质被成功地应用于捕获葡萄糖，莽草酸和奎尼酸。方法用于3-氯-1，3-二氧戊环的测定，植物油中的2-丙二醇.图形摘要.基质辅助激光解吸/电离飞行时间质谱法检测顺式二醇化合物的方法示意图使用氮化硼（BN）/α-氰基-4-羟基肉桂酸（CHCA）的二元基质，用MALDI-TOF MS进行分析。（3-（吖啶-9-基氨基）苯基）硼酸（AYPBA）。
A MALDI-TOF mass spectrometric method is described for the determination of small molecule compounds with cis-diol. It is based on the use of a binary matrix consisting of boron nitride (BN) and α-cyano-4-hydroxycinnamic acid that was modified with the derivatization reagent of (3-(acridin-9-ylamino)phenyl)boronic acid which can recognize cis-diols. The binary matrix is used for desorption/ionization (DI) in the positive ion mode. The mechanism leading to DI enhancement was investigated. The results imply that BN is beneficial for the DI because it induces an enhancement in the positive ion mode. The boronic acid-functionalized binary matrix was successfully applied to capture the glucose, shikimic acid and quinic acid. The method was applied to the determination of 3-chloro-1,2-propanediol in plant oil.Graphical abstractSchematic representation of a method for detecting the cis-diol compounds on matrix assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) using the binary matrix of boron nitride (BN)/α-cyano-4-hydroxycinnamic acid (CHCA) that was modified with (3-(acridin-9-ylamino)phenyl) boronic acid (AYPBA).