Additional B-cell malignancies in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL).
Additional B-cell malignancies in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL).
复制标题
慢性淋巴细胞白血病/小淋巴细胞淋巴瘤 (CLL) 患者的其他 B 细胞恶性肿瘤。
DOI：
10.1080/10428194.2020.1737690
复制
发表时间：
2020
影响因子：
2.6
通讯作者：
Zent,CliveS
中科院分区：
文献类型：
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作者：
Meacham,PhilipJ;Williams,AnnaLynnM;Strawderman,Myla;Baran,AndreaM;Archibald,WilliamJ;Wallace,DanielleS;Tschernia,NicholasP;Burack,WalterRichard;Barr,PaulM;Zent,CliveS
家族和迁移研究表明，发生慢性淋巴细胞性白血病/小淋巴细胞性淋巴瘤(CLL)的遗传风险。我们假设，慢性淋巴细胞性白血病患者患上更多克隆性无关的B细胞恶性肿瘤的风险增加。为了验证这一点，我们研究了467名慢性淋巴细胞性白血病患者(2743人年(PY))，他们在一家机构工作了17个 年。任何额外的B细胞淋巴系统恶性肿瘤的发病率(IR)为10.9/1000Pys(n= 30，6.4%)。18例(4%)患者有克隆性无关的B细胞恶性肿瘤(IR = 为6.6/1000Pys)。标准化发病率比率(SIRS)被用来比较CLL患者中额外的克隆性无关B细胞恶性肿瘤的发病率与美国监测、流行病学和最终结果(SEER)数据库中年龄和性别匹配的预期发病率。对于在SEER数据库中有数据进行比较的13名患者的子集，SIR为5.41(95%CI = 2.9，9.3)，这支持我们的假设。
Family and migration studies suggest a genetic risk of developing chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL). We hypothesized that CLL patients have an increased risk of additional clonally unrelated B-cell malignancies. To test this, we studied 467 CLL patients (2743 person-years (PYs)) at a single institution over 17 years. The incidence rate (IR) of any additional B-cell lymphoid malignancy was 10.9 per 1000 PYs (n= 30, 6.4%). Eighteen (4%) patients had a clonally unrelated B-cell malignancy (IR = 6.6 per 1000 PYs). Standardized incidence ratios (SIRs) were used to compare the incidence of additional clonally unrelated B-cell malignancies in CLL patients to the age- and sex-matched expected rates in the USA generated from the Surveillance, Epidemiology, and End Results (SEER) database. For the subset of 13 patients having data for comparison in the SEER database, the SIR was 5.41 (95% CI = 2.9, 9.3) which is supportive of our hypothesis.