Pimecrolimus 1% cream for pruritus in postmenopausal diabetic women with vulvar lichen simplex chronicus: A prospective non‐controlled case series
Pimecrolimus 1% cream for pruritus in postmenopausal diabetic women with vulvar lichen simplex chronicus: A prospective non‐controlled case series
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1%吡美莫司乳膏治疗患有外阴慢性单纯性苔藓的绝经后糖尿病女性的瘙痒：前瞻性非对照病例系列
DOI：
10.1080/09546630801955341
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Sefa Kelekci˙
中科院分区：
文献类型：
--
作者：
Handan Ki˙ymet Kelekci˙;H. Uncu;Bulent Yi˙lmaz;Orcun Ozdemi˙r;N. Sut;Sefa Kelekci˙
背景：外阴瘙痒可能有多种原因，如感染、皮肤病或非肿瘤性/肿瘤性外阴疾病。目的：观察1%吡美莫司乳膏外用治疗外阴瘙痒的疗效和不良反应。方法：12例绝经后糖尿病合并外阴慢性单纯性苔藓患者作为研究对象。每例患者均用1%吡美莫司乳膏外阴薄层涂抹，每日两次，疗程3个月。在治疗前、治疗后4周和治疗3个月后，由同一医生进行临床检查并使用评分系统记录患者的症状。结果：所有患者均完成研究。治疗后第4周(2.17±0.72，p<；0.0 1)和3个月(0.42±0.92，p<；0.001)的瘙痒症状较治疗前(3.75±0.45)显著减少。治疗3个月后随访，痊愈10例(83.3%)，瘙痒症状改善2例(16.7%)。结论：1%吡美莫司乳膏是治疗绝经后女性外阴慢性单纯性苔藓瘙痒的一种安全有效的方法。
Background: Pruritus vulvae may have a variety of causes, such as infections, dermatologic disorders or non‐neoplastic/neoplastic vulvar diseases. Objectives: To investigate the efficacy and side effects of topical pimecrolimus 1% cream for pruritus vulvae. Methods: Twelve postmenopausal diabetic women with vulvar lichen simplex chronicus were enrolled in this trial. Each patient was treated with pimecrolimus 1% cream which was applied twice daily in a thin layer to the vulvae for 3 months. Clinical examination and recording of patients' symptoms using a scoring system was performed by the same physician before, after 4 weeks and after 3 months of therapy. Results: All of the patients completed the study. A substantial decrease in pruritus after treatment was reported by the patients at the 4th week (2.17±0.72, p<0.01) and 3rd month of treatment (0.42±0.92, p<0.001) when compared with the baseline score (3.75±0.45). Follow‐up of the patients after 3 months of treatment showed that complete cure occurred in 10 patients (83.3%) and the pruritus was improved in two (16.7%) patients. Conclusions: Pimecrolimus 1% cream seems to be an effective and safe treatment modality for pruritus in postmenopausal women with vulvar lichen simplex chronicus.