CaM Kinase II and Visual Input Modulate Memory Formation in the Neuronal Circuit Controlling Courtship Conditioning
CaM Kinase II and Visual Input Modulate Memory Formation in the Neuronal Circuit Controlling Courtship Conditioning
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DOI：
10.1523/jneurosci.17-23-09384.1997
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发表时间：
1997-12
期刊：
影响因子：
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通讯作者：
M. A. Joiner;Leslie C. Griffith
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文献类型：
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作者：
M. A. Joiner;Leslie C. Griffith
在果蝇中，钙/钙调素依赖性蛋白激酶II （CaM激酶）已被证明在求爱条件反射的联想行为的学习和记忆表达中起重要作用。在这项研究中，我们研究了视觉输入在产生这种行为中的作用，以及修改视觉输入对CaM激酶依赖性记忆形成的影响。无论视觉输入如何，CaM激酶的抑制都会阻断表观学习。视觉输入选择性地影响了求偶条件反射的记忆阶段：正常的视觉输入掩盖了CaM激酶抑制的记忆效应，导致记忆的产生而没有明显的学习，而视觉输入的中断揭示了记忆的CaM激酶依赖性。视觉输入仅在训练期间起重要作用，这意味着视觉和CaM激酶在记忆的形成过程中相互作用，而不是在记忆的提取过程中相互作用。我们的研究结果提出了一种求偶条件反射模型，在该模型中，多种感觉输入在cam激酶依赖的神经元开关上整合，以调节求偶行为。
In Drosophila, calcium/calmodulin-dependent protein kinase II (CaM kinase) has been shown to be important in the expression of both learning and memory for the associative behavior courtship conditioning. In this study we examine the role of visual input in producing this behavior and the effects of modifying visual input on CaM kinase-dependent memory formation. Inhibition of CaM kinase blocked apparent learning regardless of visual input. Visual input selectively affected the memory phase of courtship conditioning: normal visual input masked the memory effects of inhibition of CaM kinase resulting in generation of memory without apparent learning, whereas disruption of visual input revealed the CaM kinase-dependence of memory. Visual input was found to be important only during the training period, which implies that vision and CaM kinase are interacting in the formation rather than the retrieval of memory. Our results suggest a model for courtship conditioning in which multiple sensory inputs are integrated at a CaM-kinase-dependent neuronal switch to modulate courtship behavior.