Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure - A randomized controlled trial
Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure - A randomized controlled trial
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DOI：
10.1001/jama.297.19.2081
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发表时间：
2007-05-16
影响因子：
120.7
通讯作者：
Blair, Steven N.
中科院分区：
文献类型：
--
作者：
Church, Timothy S.;Earnest, Conrad P.;Blair, Steven N.
背景低水平的心肺健康与高死亡风险相关，健康的改善与死亡风险的降低相关。然而，对体力活动-健身剂量反应关系的理解仍然很差。目的研究50%，100%和150%的NIH共识发展小组推荐的体力活动剂量对女性健身的影响。设计，设置和参与者随机对照试验464名久坐，绝经后超重或肥胖女性，体重指数范围为25.0 - 43.0，收缩压范围为120.0 - 159.9 mm Hg。参与者于2001年4月至2005年6月在德克萨斯州的达拉斯地区被随机分配到4组中的1组：102名为非运动对照组，155名为每周4千卡/千克、104名为8千卡/千克和103名为12千卡/千克的能量消耗组，为期6个月。目标训练强度是与每个妇女的峰值（V）超过点O-2的50%相关的心率。主要结果测量主要结果是在自行车测力计上评估的有氧适应性，并量化为峰值绝对耗氧量（（V）超过点O（2）abs，结果基线时平均（SD）V/dotO（2）abs值为1.30每周平均运动时间为72.2分钟（12.3）、（135.8）、（19.5）和（191.7）。在调整了年龄、种族、体重和峰值心率后，与对照组相比，每周4千卡/公斤、8千卡/公斤和12千卡/公斤的运动组的（V）/点O（2）abs增加了4.2%、6.0%和8.2%（P
Context Low levels of cardiorespiratory fitness are associated with high risk of mortality, and improvements in fitness are associated with reduced mortality risk. However, a poor understanding of the physical activity - fitness dose response relation remains.Objective To examine the effect of 50%, 100%, and 150% of the NIH Consensus Development Panel recommended physical activity dose on fitness in women.Design, Setting, and Participants Randomized controlled trial of 464 sedentary, postmenopausal overweight or obese women whose body mass index ranged from 25.0 to 43.0 and whose systolic blood pressure ranged from 120.0 to 159.9 mm Hg. Enrollment took place between April 2001 and June 2005 in the Dallas, Tex, area.Intervention Participants were randomly assigned to 1 of 4 groups: 102 to the non-exercise control group and 155 to the 4-kcal/kg, 104 to the 8-kcal/kg, and 103 to the 12-kcal/kg per week energy-expenditure groups for the 6-month intervention period. Target training intensity was the heart rate associated with 50% of each woman's peak (V) over dot O-2.Main Outcome Measure The primary outcome was aerobic fitness assessed on a cycle ergometer and quantified as peak absolute oxygen consumption ((V) over dot O(2)abs, L/min).Results The mean (SD) baseline (V) over dot O(2)abs values were 1.30 (0.25) L/min. The mean ( SD) minutes of exercising per week were 72.2 (12.3) for the 4-kcal/kg, 135.8 (19.5) for the 8-kcal/ kg, and 191.7 (33.7) for the 12-kcal/kg per week exercise groups. After adjustment for age, race/ethnicity, weight, and peak heart rate, the exercise groups increased their (V) over dot O(2)abs compared with the control group by 4.2% in the 4-kcal/kg, 6.0% in the 8-kcal/ kg, and 8.2% in the 12-kcal/ kg per week groups ( P