Continuous microfluidic immunomagnetic cell separation
Continuous microfluidic immunomagnetic cell separation
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DOI：
10.1063/1.1823015
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发表时间：
2004-11-22
影响因子：
4
通讯作者：
Sturm, JC
中科院分区：
文献类型：
--
作者：
Inglis, DW;Riehn, R;Sturm, JC
我们提出了一种连续流动的微流体装置，使细胞的细胞分离选择性标记的磁性纳米粒子。这些细胞流过一系列微制造的磁条，这些磁条产生一系列高磁场梯度，捕获磁性标记的细胞并改变它们的流动方向。使用低倍显微镜在真实的时间内观察该过程。该装置已通过从人全血中分离白细胞得到证实。(C)2004年，美国物理学会。
We present a continuous-flow microfluidic device that enables cell by cell separation of cells selectively tagged with magnetic nanoparticles. The cells flow over an array of microfabricated magnetic stripes, which create a series of high magnetic field gradients that trap the magnetically labeled cells and alter their flow direction. The process was observed in real time using a low power microscope. The device has been demonstrated by the separation of leukocytes from whole human blood. (C) 2004 American Institute of Physics.