Carbachol injections into the nucleus accumbens induce 50 kHz calls in rats
Carbachol injections into the nucleus accumbens induce 50 kHz calls in rats
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DOI：
10.1016/j.neulet.2006.02.069
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发表时间：
2006-06-19
影响因子：
2.5
通讯作者：
Schnitzler, Hans-Ulrich
中科院分区：
文献类型：
--
作者：
Fendt, Markus;Schwienbacher, Isabel;Schnitzler, Hans-Ulrich
在老鼠身上，可以观察到不同类型的发声。高频发声(所谓的50千赫叫声)被认为表明发出声音的动物的食欲状态。研究表明，将多巴胺激动剂苯丙胺注入伏隔核(NAC)，这是食欲行为的关键结构，可以诱导50千赫的叫声，这一点得到了支持。过去几年的几项研究表明，不仅向NAC注入安非他明等多巴胺激动剂，而且向NAC注入乙酰胆碱受体激动剂，也能刺激食欲系统。在目前的研究中，我们测试了向NAC内注入非特异性胆碱能激动剂卡巴胆碱是否能够诱导50 kHz的叫声。事实上，我们观察到在NAC内注入氨基甲胆碱后，有大量的50 kHz的叫声。这些呼叫的主要频率在40~70 kHz之间，持续时间主要在10~50ms之间。我们假设，乙酰胆碱在NAC内的传递在诱导那些表明食欲状态的超声叫声中起着重要作用。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
In rats, different types of vocalization can be observed. High frequency vocalizations (so called 50 kHz calls) are believed to indicate an appetitive state of the emitting animal. This is supported by studies demonstrating that infusions of the dopamine agonist amphetamine into the nucleus accumbens (NAC), a key structure for appetitive behaviors, induce 50 kHz calls. Several studies during the last years demonstrated that not only infusions of dopamine agonists such amphetamine but also infusions of acetylcholine receptor agonists into the NAC stimulate the appetitive system. In present study, we tested whether infusions of the unspecific cholinergic agonist carbachol into the NAC are able to induce 50 kHz calls. Indeed, we observed a high number of 50 kHz calls after intra-NAC infusions of carbachol. The main frequency of the these calls was between 40 and 70 kHz, and the duration was mainly between 10 and 50 ms. We hypothesize that acetylcholine transmission within the NAC plays an important role in the induction of those ultrasonic calls indicating an appetitive state. (c) 2006 Elsevier Ireland Ltd. All rights reserved.