Hybrid ZnO Nanorod-Polymer Brush Hierarchically Nanostructured Substrate for Sensitive Antibody Microarrays

Hybrid ZnO Nanorod-Polymer Brush Hierarchically Nanostructured Substrate for Sensitive Antibody Microarrays
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用于敏感抗体微阵列的混合氧化锌纳米棒-聚合物刷分层纳米结构基底

DOI:
10.1002/adma.201403712
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发表时间:
2015-01-01
期刊:
影响因子:
29.4
通讯作者:
Li, Chang Ming
Li, Chang Ming
中科院分区:
材料科学1区
文献类型:
--
作者:
Hu, Weihua;Liu, Yingshuai;Li, Chang Ming

文献摘要

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报道了一种分层纳米结构的有机-无机混合基底,其包含在载玻片上的随机取向的ZnO纳米棒和同轴拴系的致密聚合物刷,POEGMA-co-GMA,用于高灵敏度的抗体微量测定,实现了优异的检测特异性,以及在1小时测定时间内对人血清中的生物标志物低至100 fg mL(-1)的上级检测限。
A hierarchically nanostructured organic-inorganic hybrid substrate comprising randomly oriented ZnO nanorods on glass slide with coaxially tethered dense polymer brush, POEGMA-co-GMA is reported for highly sensitive antibody microassay, achieving excellent detection specificity, and superior detection limit of as low as 100 fg mL (-1) for biomarkers in human serum within a 1 h assay time.