Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people -: The cardiovascular health study
Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people -: The cardiovascular health study
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DOI：
10.1001/archneur.55.9.1217
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发表时间：
1998-09-01
影响因子：
--
通讯作者：
Price, TR
中科院分区：
文献类型：
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作者：
Longstreth, WT;Bernick, C;Price, TR
目的：为了确定老年人腔隙性脑梗死的危险因素和功能后果：心血管健康研究（CHS）是一项纵向研究的人65岁或以上，其中3660名参与者进行了颅磁共振成像（MRI）。神经放射科医生以标准的方式阅读扫描，没有任何临床信息。腔隙被定义为皮质下区与梗死测量3至20 mm. In横断面分析，临床相关性进行了对比组之间定义的MRI findings.Results：在3660例接受MRI检查，2529（69%）是免费的梗死的任何一种和841（23%）有1个或多个腔隙没有其他类型的存在，共1270腔隙。对于这841名受试者中的大多数，他们的腔隙是单一的（66%）和沉默的（89%），即没有短暂性脑缺血发作或中风的历史。在多变量分析中，与骨陷窝独立相关的因素有年龄增加、舒张压、肌酐和吸烟包年数（按关联强度降序排列;对于所有因素，P
Objective: To identify risk factors for and functional consequences of lacunar infarct in elderly people.Methods: The Cardiovascular Health Study (CHS) is a longitudinal study of people 65 years or older, in which 3660 participants underwent cranial magnetic resonance imaging (MRI). Neuroradiologists read scans in a standard fashion without any clinical information. lacunes were defined as subcortical areas consistent with infarcts measuring 3 to 20 mm. In cross-sectional analyses, clinical correlates were contrasted among groups defined by MRI findings.Results: Of the 3660 subjects who underwent MRI, 2529 (69%) were free of infarcts of any kind and 841 (23%) had 1 or more lacunes without other types present, totaling 1270 lacunes. For most of these 841 subjects, their lacunes were single (66%) and silent (89%), namely without a history of transient ischemic attack or stroke. In multivariate analyses, factors independently associated with lacunes were increased age, diastolic blood pressure, creatinine, and pack-years of smoking (listed in descending order of strength of association; for all, P