Possible Role of Inflammation and Galectin-3 in Brain Injury after Subarachnoid Hemorrhage.
Possible Role of Inflammation and Galectin-3 in Brain Injury after Subarachnoid Hemorrhage.
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DOI：
10.3390/brainsci8020030
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发表时间：
2018-02-07
期刊：
影响因子：
3.3
通讯作者：
Suzuki H
中科院分区：
文献类型：
--
作者：
Nishikawa H;Suzuki H
动脉瘤性蛛网膜下腔出血（SAH）被认为是中枢神经系统最具破坏性的疾病之一。在过去的几十年里，对SAH的研究集中在脑血管痉挛，以防止SAH后迟发性脑缺血（DCI）和改善预后。然而，越来越多的证据表明，早期脑损伤（EBI）是导致DCI、脑血管痉挛以及不良结局的重要机制。尽管EBI的发病机制非常复杂，但炎症被认为在EBI中起着关键作用。半乳糖凝集素-3是半乳糖凝集素家族中独特的嵌合体类型，其特征在于其β-半乳糖苷结合凝集素，其介导各种病理学，如纤维化、细胞粘附和炎症。最近，两项临床研究显示半乳糖凝集素-3可能是SAH患者的预后生物标志物。此外，我们最近的报告表明，较高的急性期血浆半乳糖凝集素-3水平与随后发生的迟发性脑梗死相关，而迟发性脑梗死与SAH患者的血管痉挛无关。本文综述了炎症和半乳糖凝集素-3在脑损伤中的可能作用和分子机制，特别是SAH后EBI，并讨论了半乳糖凝集素-3作为SAH后脑损伤潜在的新治疗或研究靶点。
Aneurysmal subarachnoid hemorrhage (SAH) is known as one of the most devastating diseases in the central nervous system. In the past few decades, research on SAH has focused on cerebral vasospasm to prevent post-SAH delayed cerebral ischemia (DCI) and to improve outcomes. However, increasing evidence has suggested that early brain injury (EBI) is an important mechanism contributing to DCI, cerebral vasospasm as well as poor outcomes. Though the mechanism of EBI is very complex, inflammation is thought to play a pivotal role in EBI. Galectin-3 is a unique chimera type in the galectin family characterized by its β-galactoside-binding lectin, which mediates various pathologies, such as fibrosis, cell adhesion, and inflammation. Recently, two clinical studies revealed galectin-3 to be a possible prognostic biomarker in SAH patients. In addition, our recent report suggested that higher acute-stage plasma galectin-3 levels correlated with subsequent development of delayed cerebral infarction that was not associated with vasospasm in SAH patients. We review the possible role and molecular mechanisms of inflammation as well as galectin-3 in brain injuries, especially focusing on EBI after SAH, and discuss galectin-3 as a potential new therapeutic or research target in post-SAH brain injuries.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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DOI：
10.1073/pnas.0511167103
发表时间：
2006-03-28
影响因子：
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作者：
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