Is Salvage Liver Resection Necessary for Initially Unresectable Hepatocellular Carcinoma Patients Downstaged by Transarterial Chemoembolization? Te Years of Experience
Is Salvage Liver Resection Necessary for Initially Unresectable Hepatocellular Carcinoma Patients Downstaged by Transarterial Chemoembolization? Te Years of Experience
复制标题
DOI：
10.1634/theoncologist.2016-0094
复制
发表时间：
2016-12-01
期刊：
影响因子：
5.8
通讯作者：
Li, Jiaping
中科院分区：
文献类型：
--
作者：
Zhang, Yingqiang;Huang, Guihua;Li, Jiaping
介绍。本研究评估了挽救性手术作为最初不可切除的 HCC 患者经动脉化疗栓塞 (TACE) 降期后的额外治疗的长期结果。方法。对2004年6月至2014年12月期间连续831例接受TACE作为初始治疗的不可切除的HCC患者进行回顾性分析。其中，82例降期可切除HCC患者纳入本研究：43例接受挽救性手术（S组），其余39例拒绝挽救性切除的对照组（T组）。主要终点是总生存期（OS）。结果。 S 组和 T 组的中位 OS 分别为 49 个月和 31 个月 (p = 0.027)。S 组的 2 年、4 年和 5 年生存率分别为 93%、47% 和 26%，T 组分别为 74%、18% 和 10% (p = 0.019)。治疗方式（风险比 [HR1，0.337；95% 保密区间 [CH，0.184-0.616；p
Introduction. This study evaluated long-term outcomes of salvage surgery as additional therapy following downstaging of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) in patients with initially unresectable HCC.Methods. A retrospective analysis was performed of 831 consecutive patients with unresectable HCC who underwent TACE as initial treatment between June 2004 and December 2014. Of these, 82 patients with downstaged resectable HCC were enrolled in this study: 43 received salvage surgery (S group) and the remaining 39, who refused salvage resection, were the control group (T group). The primary endpoint was overall survival (OS).Results. The median OS in the S and T groups was 49 and 31 months, respectively (p =.027).The 2-, 4-, and 5-year survival rates were 93%, 47%, and 26% in the S group and 74%, 18%, and 10% in the T group, respectively (p =.019). Treatment modality (hazard ratio [HR1, 0.337; 95% confidential interval [CH, 0.184-0.616; p