Inter- and intra-animal variation of integrative properties of stellate cells in the medial entorhinal cortex
Inter- and intra-animal variation of integrative properties of stellate cells in the medial entorhinal cortex
复制标题
内侧内嗅皮层星状细胞整合特性的动物间和动物内变异
DOI：
10.1101/678565
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Pastoll H
中科院分区：
文献类型：
--
作者：
Pastoll H
细胞类型之间的差异是神经系统功能组织原理的基础，但同样清楚的是，相同类型的神经元之间存在功能差异。网格细胞空间尺度与内侧内嗅皮层星状细胞（SCs）的突触整合特性之间的对应关系证明了这一点。然而，我们对这种可变性是如何在个体内部或个体之间形成的知之甚少。为了解决这个问题，我们使用离体膜片钳记录来确定每只小鼠的许多（多达55个）SCs的整合特性。我们发现SC整合特性的表达和地形调节在小鼠之间有所不同，部分取决于经验，与网格细胞空间尺度的模块化相反，具有连续的背腹组织。我们的研究结果限制了模块网格放电的机制，并为相同类型的神经元之间的基础和经验依赖的动物间表型变异性提供了证据。
Distinctions between cell types underpin organisational principles for nervous system function, but it is also clear that functional variation exists between neurons of the same type. This is exemplified by correspondence between grid cell spatial scales and synaptic integrative properties of stellate cells (SCs) in the medial entorhinal cortex. However, we know little about how this variability is structured either within or between individuals. To address this, we used ex-vivo patch-clamp recordings to determine integrative properties from many (up to 55) SCs per mouse. We find that the expression and topographic tuning of SC integrative properties varies between mice, is in part dependent on experience and, in contrast to modularity of grid cell spatial scales, has a continuous dorsoventral organisation. Our results constrain mechanisms for modular grid firing and provide evidence for basal and experience-dependent inter-animal phenotypic variability among neurons of the same type.