Two-dimensional manipulation and orientation of actin-myosin systems with dielectrophoresis
Two-dimensional manipulation and orientation of actin-myosin systems with dielectrophoresis
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DOI：
10.1021/nl0259434
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发表时间：
2003-04-01
期刊：
影响因子：
10.8
通讯作者：
Superfine, R
中科院分区：
文献类型：
--
作者：
Asokan, SB;Jawerth, L;Superfine, R
分子马达作为一种自主传输和传感系统，在分析和机电系统等纳米技术中发挥着重要作用。建立对沉积模式的控制和控制分子运动诱导的运输是很重要的。应用电信号来控制运动是必要的，因为它们与硅电子集成。我们用四极电极应用介电泳（DEP）力在衬底上形成肌动蛋白的图案。此外，DEP扭矩指导肌动蛋白沿着电场线在肌凝蛋白底物上的运动。这是我们迈向芯片集成生物运动分析系统的第一步。
Molecular motors, as autonomous transporting and sensing systems, may play an important role in nanoscale technologies such as analytical and electromechanical systems. It is important to establish control of the patterning of deposition and to control the molecular motor-induced transport. Application of electrical signals to control motor motility is necessary for their integration with silicon electronics. We have applied dielectrophoretic (DEP) forces with quadrupole electrodes to pattern actin on a substrate. In addition, DEP torque(s) directed the motion of actin on myosin substrates along electric field lines. These are our first steps toward building an on-chip, integrated, biomotor analytical system.